As with other topical corticosteroids prolonged use of large amount or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism. This effect is more likely to occur in infants and children, and if occlusive dressings are used. In infants, the napkin may act as an occlusive dressing. Provided the weekly dosage is less than 50 mg in adults, any suppression of the HPA axis is likely to be transient with a rapid return to normal values once the short course of steroid therapy ceased.
Prolonged and intensive treatment with highly-active corticosteroid preparations may cause local atrophic changes such as striae, thinning of the skin, and dilatation of the superficial blood vessel, particularly when occlusive dressings are used, or where skin folds are involved. In rare instances, treatment of psoriasis with corticosteroids (or its withdrawal) is thought to provoke the pustular form of the disease.
There are reports of pigmentation changes and hypertrichosis with topical steroids.
Uniderm Cream is usually well tolerated, but if any signs of the above reactions appear, application should be stopped immediately.