Brompheniramine maleate, Phenylephrine hydrochloride.
Each 5 mL contains: Brompheniramine maleate 4 mg, Phenylephrine HCl 10 mg.
Antihistamines used in the treatment of allergy act by competing with histamine for H1-receptor sites in effector cells. They thereby prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effect of histamine, including urticaria and pruritus. Also, the anticholinergic actions of most antihistamines provide a drying effect on the nasal mucosa. Antihistamines prevent responses to acetylcholine that are mediated via muscarinic receptors.
Symptomatic treatment for the temporary relief of nasal and sinus congestion, sneezing and rhinorrhea associated with the common cold and allergic rhinitis.
The amount as follows to be taken 3 to 4 times daily: Adults: 5 mL (1 teaspoonful).
Children (6-12 years): 2.5 mL (1/2 teaspoonful).
Contraindicated to any of the antihistamines or sympathomimetic amines.
Other medical problems, especially cardiovascular disease, diabetes, hepatic function impairment, hypertension, hyperthyroidism, prostatic hypertrophy, or renal function impairment.
May cause drowsiness or dizziness.
Avoid alcoholic beverages or other CNS depressants. Not taking more medication than the amount recommended.
Use in children: increased susceptibility to anticholinergic effects of antihistamines and to vasopressor effect of sympathomimetic amines; psychiatric disorders more likely with the use of phenylpropanolamine in children under 6 years of age; hyperexcitability (paradoxical reaction) may occur.
Use in the elderly: Anticholinergic and CNS stimulant effects more likely to occur.
Breast-feeding: antihistamines may cause excitement or irritability in nursing infants; high risk for infants from sympathomimetic amines.
Signs of potential side effects, especially blood dyscrasias, cardiac arrhythmias, psychotic episodes, and tightness in chest.
To date, there are no known interactions with other drugs. Nevertheless, caution is recommended if sedative are also being taken.
Store at temperature not more than 30°C.
R01BA53 - phenylephrine, combinations ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants.