May cause hypotension; hyperthyroidism. Perform thyroid function tests as clinically indicated. Patients w/ pulmonary veno-occlusive disease. Concomitant use w/ moderate CYP2C8 inhibitors. Minor influence on the ability to drive & use machines. Should not be administered in patients w/ severe liver impairment (Child-Pugh class C), severe renal impairment (eGFR <30 mL/min/1.73 m2
), & in patients undergoing dialysis. Women of childbearing potential should practice effective contraception while on treatment. Not recommended during pregnancy & in women of childbearing potential not using contraception. Should not be used during breast-feeding. Elderly >75 yr.