Vagifem諾舒芬

Vagifem

estradiol

Manufacturer:

Novo Nordisk

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Estradiol
Indications/Uses
Vaginal atrophy due to oestrogen deficiency in postmenopausal women.
Dosage/Direction for Use
Initial dose: 1 vag tab/day for 2 wk. Maintenance dose: 1 vag tab twice wkly.
Contraindications
Hypersensitivity. Known, past or suspected breast cancer, oestrogen-dependent malignant tumours; undiagnosed genital bleeding, untreated endometrial hyperplasia, previous or current venous thromboembolism, known thrombophilic disorders, active or recent arterial thromboembolic disease, acute liver disease, history of liver disease, porphyria. Pregnancy & lactation.
Special Precautions
Leiomyoma or endometriosis, thromboembolic disorders, risk factors for estrogen-dependent tumours, HTN, liver disorders, DM w/ or w/o vascular involvement, cholelithiasis, migraine or severe headache, SLE, endometrial hyperplasia history, epilepsy, asthma, otosclerosis.
Adverse Reactions
Headache, abdominal pain, vag haemorrhage, discharge & discomfort.
Drug Interactions
Increased metabolism w/ phenobarb, phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz; ritonavir, nelfinavir, St. John's wort.
ATC Classification
G03CA03 - estradiol ; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.
Presentation/Packing
Form
Vagifem vag tab 10 mcg
Packing/Price
(w/ applicator) 18's
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