Valaciclovir Sandoz

Valaciclovir Sandoz





Concise Prescribing Info
Valaciclovir HCl
Treatment of herpes zoster (shingles) & ophth zoster in immunocompetent adults. Treatment of herpes zoster in adult patients w/ mild or moderate immunosuppression. Treatment & suppression of HSV infections of the skin & mucous membranes. Treatment & suppression of recurrent ocular HSV infections. Prophylaxis of cytomegalovirus (CMV) infection & disease following solid organ transplantation in adults & adolescents.
Dosage/Direction for Use
Herpes zoster & ophth zoster Immunocompetent adult 1,000 mg tds for 7 days. Immunocompromised adult 1,000 mg tds for at least 7 days & for 2 days following crusting of lesions. HSV infections Immunocompetent adult & adolescent ≥12 yr 500 mg bd for 10 days (initial episodes) or 3-5 days (recurrent episodes). Immunocompromised adult 1,000 mg bd for at least 5 days or 10 days (initial episodes). Herpes labialis Initially 2,000 mg bd for 1 day. 2nd dose to be taken 12 hr after 1st dose. Suppression of recurrences of HSV infections Immunocopetent adult & adolescents ≥12 yr 500 mg once daily. Immunocompromised adult 500 mg bd. Prophylaxis of CMV infection & disease Adult & adolescent ≥12 yr 2,000 mg qds for 90 days but may need to be extended in high-risk patients.
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Special Precautions
Ensure adequate fluid intake in patients who are at risk of dehydration particularly the elderly. Renal impairment. Hepatic impairment & liver transplantation. Close monitoring of clinical response particularly in immunocompromised patients & in ocular HSV infection patients. Avoid intercourse when symptoms are present even if treatment w/ an antiviral has been initiated. Use in CVM infections in transplant patients. Pregnancy & lactation. Childn <12 yr. Elderly.
Adverse Reactions
Headache, nausea; dizziness; vomiting, diarrhoea; rashes including photosensitivity, pruritus.
Drug Interactions
Increased nephrotoxicity w/ other nephrotoxic medicinal products eg, aminoglycosides, organoplatinum compd, iodinated contrast media, methotrexate, pentamidine, foscarnet, ciclosporin & tacrolimus. Reduced renal clearance & increased AUC of aciclovir w/ cimetidine & probenecid. Increased aciclovir conc w/ tenofovir. Increase in plasma AUCs of aciclovir & inactive metabolite of mycophenolate mofetil when co-administered. Use caution when co-administered w/ drugs which inhibit active renal tubular secretion.
MIMS Class
ATC Classification
J05AB11 - valaciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Valaciclovir Sandoz FC tab 500 mg
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