Vastia Dosage & Drug Information

Concise Prescribing Info

Contents

Donepezil HCl

Indications/Uses

Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

Dosage/Direction for Use

Adult/elderly Initially 5 mg/day in the evening for at least 1 mth. Max: 10 mg/day.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to donepezil & piperidine derivatives.

Special Precautions

Severe Alzheimer's dementia, other types of dementia & memory impairment. Heart block, long sinus pauses, increased risk of ulcers, bladder outflow obstruction, exacerbation or induction of extrapyramidal symptoms, history of asthma, or obstructive pulmonary disease. Galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption. Severe hepatic impairment. Pregnancy & lactation.

Adverse Reactions

Diarrhoea, muscle cramps, fatigue, nausea, vomiting, insomnia, headache.

View ADR Monitoring Form

Drug Interactions

Increased conc w/ ketoconazole, quinidine, CYP3A4 (itraconazole, erythromycin) & 2D6 inhibitors (fluoxetine). Decreased conc w/ rifampicin, phenytoin, carbamazepine & alcohol. Synergistic activity w/ succinylcholine, other neuromuscular blockers, cholinergic agonists, β-blockers.

MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.

Regulatory Classification

P₁S₁S₃

Presentation/Packing

Form

Vastia tab 10 mg

Packing/Price

100's

Form

Vastia tab 5 mg

Packing/Price

100's

Vastia

donepezil

Manufacturer:

Korea Pharma

Distributor:

SB Pharma