Side effects which have been reported more frequently than in isolated cases are listed below according to organ system and frequency.
Frequency is defined on the basis of the following convention: Very common (>1/10); Common (>1/100, <1/10); Uncommon (>1/1,000, <1/100); Rare (>1/10,000, <1/1,000); Very rare (<1/10,000), or unknown.
Infections and Infestations:
Blood and lymphatic system disorders:
Very common: Neutropenia, anemia.
Common: thrombocytopenia, febrile neutropenia, neutropenic sepsis with potentially fatal outcome.
Immune system disorders:
Common: Allergic reactions (skin reactions, respiratory disorders).
Metabolism and nutrition disorders:
Very rare: Syndrome of inadequate antidiuretic hormone hypersecretion (SIADH).
Nervous system disorders:
Very common: Constipation (see also "Gastrointestinal disorders"), loss of deep tendon reflexes.
Common: Paresthesia with sensorimotor symptoms.
Rare: Loss of strength of the lower extremities, paralytic ileus (see also "Gastrointestinal disorders").
Very rare: Guillain-Barre Syndrome.
Rare: Coronary heart disease, such as angina pectoris, ECG modifications, myocardial infarction.
Respiratory, thoracic and mediastinal disorders:
Common: Dyspnoea, bronchial spasms.
Rare: Interstitial lung disease.
Very common: Constipation (see also "Nervous system disorders"), nausea, vomiting, diarrhoea, stomatitis, oesophagitis, anorexia.
Rare: Pancreatitis, paralytic ileus (see also "Nervous system disorders").
In the case of paralytic ileus, treatment can be resumed when normal gastrointestinal function has been restored.
Liver and gallbladder disorders:
Very common: Changed hepatic function values (elevated total bilirubin, elevated alkaline phosphatase, elevated aspartate aminotransferase, elevated alanin aminotransferase).
Skin and subcutaneous tissue disorders:
Very common: Alopecia.
Common: Skin reactions.
Musculoskeletal and connective tissue disorders and bone disease:
Common: Myalgia, arthralgia.
Rare: Pain in the jaws.
Renal and urinary disorders:
Common: Elevated creatinine.
General disorders and administration site disorders:
Very common: Fatigue, fever, pain in various places, asthenia, erythema at the injection point, pain at the injection point, discoloration at the injection point, phlebitis at the injections point.
Rare: Necrosis at the injection site.