Addisonian pernicious anaemia & other macrocytic anaemias w/o neurological involvement Initially: 250-1,000 mcg IM on alternate days for 1-2 wk, then 250 mcg wkly until the blood count is normal. Maintenance: 1,000 mcg mthly. Addisonian pernicious anaemia & other macrocytic anaemias, anaemias w/ neurological complications Initially: 1,000 mcg IM on alternate days. Prophylaxis of macrocytic anaemia associated w/ vit B12 deficiency resulting from gastroectomy, some malabsorption syndromes & strict vegetarism 250-1,000 mcg mthly. Schilling test 1,000 mcg IM.
Regular exam of blood is advisable. Folate metabolism should be investigated if megaloblastic anaemia fails to respond to therapy. Haematological response in patients w/ folate deficiency. Cardiac arrhythmias secondary to hypokalaemia during initial therapy. Monitor K plasma during this period. Not for treatment of megaloblastic anaemia of pregnancy.