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Full Prescribing Info
Glucosamine sulfate.
Each Vorifend 500 mg film-coated tablet contains 500 mg of glucosamine sulfate (as glucosamine sulfate potassium chloride equivalent to 392.6 mg of glucosamine base).
Pharmacology: Pharmacodynamics: Glucosamine is a natural substance found in chitin, mucoproteins, and mucopolysaccharides. It is involved in the manufacture of glycosaminoglycan, which forms cartilage tissue in the body; glucosamine is also present in tendons and ligaments. Glucosamine must be synthesised by the body but the ability to do this declines with age. Glucosamine and its salts have therefore been given for their supposed chondroprotective action in musculoskeletal and joint disorders including osteoarthritis. Glucosamine may be isolated from chitin or prepared synthetically; glucosamine sulfate and hydriodide, have also been used.
Symptomatic relief of mild to moderate osteoarthritis of the knee.
Dosage/Direction for Use
Dosage: Adults over 18 years: Take 3 tablets once daily. Review treatment if no benefit after 2-3 months.
Administration: Vorifend 500 mg is administered orally.
No information available.
Shellfish allergy.
Special Precautions
Impaired glucose tolerance (monitor blood-glucose concentration before treatment and periodically thereafter).
Predisposition to cardiovascular disease (monitor cholesterol).
Use In Pregnancy & Lactation
Manufacturer advises avoid - no information available.
Adverse Reactions
Nausea, abdominal pain, dyspepsia, flatulence, diarrhoea, constipation, drowsiness, headache, fatigue.
Less common: flushing, rash, pruritus.
Also reported: hypercholesterolaemia, visual disturbances, hair loss.
Drug Interactions
There have been reports of an increased international normalised ratio (INR) values in patients taking warfarin and dietary supplements containing glucosamine with or without chondroitin.
Patients on warfarin should not take glucosamine.
Store in a well-closed container, in a dry place. Do not store above 30°C.
ATC Classification
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
FC tab 500 mg (pink, oval-shaped, biconvex, plain on both sides) x 6 x 10's.
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