Severe or disabling anxiety & agitation; control of status epilepticus, epileptic & febrile convulsions; relief of muscle spasm; as a sedative in minor surgical & dental procedures or other circumstances in which a rapid effect is required.
Dosage/Direction for Use
AdultSevere anxiety or acute muscle spasm 10 mg IV or IM repeated after 4 hr. Tetanus 0.1-0.3 mg/kg IV repeated every 1-4 hr or a continuous infusion of 3-10 mg/kg every 24 hr or similar doses may be given by nasoduodenal tube. Status epilepticus or epileptic convulsions 0.15-0.25 mg/kg (usually 10-20 mg) IV inj may be repeated after 30-60 min (max of 3 mg/kg over 24 hr). Minor surgical procedures & dentistry 0.1-0.2 mg/kg by inj (usually 10-20 mg). ChildnStatus epilepticus or febrile convulsions 0.2-0.3 mg/kg IV inj repeated after 30-60 min. Sedation or muscle relaxation Up to 0.2 mg/kg parenterally.
Contraindications
Hypersensitivity to benzodiazepines. Severe or acute resp insufficiency/depression, sleep apnoea syndrome, severe hepatic insufficiency. Not to be used in phobic or obsessional state nor be used alone in treatment of depression or anxiety associated w/ depression, not for primary treatment of psychotic illness, not be used in cases of loss or bereavement. Neonates (due to benzyl alcohol).
Special Precautions
Renal or hepatic dysfunction, chronic pulmonary insufficiency, porphyria, muscle weakness, myasthenia gravis, coma, history of drug or alcohol abuse, organic brain changes particularly arteriosclerosis; personality disorders. Avoid abrupt discontinuation. May induce anterograde amnesia. Benzyl alcohol poisoning w/ prolonged use of high-dose IV infusions & may cause toxic reactions & anaphylactoid reactions in infants & childn up to 3 yr. Patient on controlled Na diet; liver disease or epilepsy. Pregnancy & lactation. Elderly.
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