Four Star
Concise Prescribing Info
Acute treatment of migraine w/ or w/o aura.
Dosage/Direction for Use
Migraine attack 2.5 mg. If symptoms persist or return w/in 24 hr give a 2nd dose w/in 2 hr of the initial dose. If satisfactory relief is not achieved, subsequent attacks can be treated w/ 5 mg doses. Max: 10 mg daily. Moderate & severe hepatic impairment Max: 5 mg daily. Renal impairment No dose adjustment required. Childn (<12 yr) & adolescent (12-17 yr) Not recommended. Elderly >65 yr Safety & efficacy have not been evaluated.
May be taken with or without food.
Hypersensitivity. Uncontrolled HTN. Ischaemic heart disease, coronary vasospasm/Prinzmetal's angina. History of CVA or transient ischaemic attack. Concomitant administration w/ ergotamine or ergotamine derivatives or other 5-HT1 receptor agonists.
Special Precautions
Exclude other potentially serious neurological conditions. Risk of certain cerebrovascular events. Do not give to patients w/ symptomatic Wolff-Parkinson-White Syndrome or arrhythmias associated w/ other cardiac accessory conduction pathways. Perform cardiovascular evaluation in patients w/ risk factors for ischaemic heart disease prior to commencement of treatment. Atypical sensations over the precordium; transient increases in systemic BP; anaphylaxis/anaphylactoid reactions. Excessive use may lead to increased frequency of headache. Reports of serotonin syndrome w/ combined use of triptans & SSRIs & serotonin norepinephrine reuptake inhibitors. Pregnancy & lactation.
Adverse Reactions
Abdominal pain, dry mouth, nausea, vomiting. Muscle weakness, myalgia. Abnormalities or disturbances of sensation, dizziness, headache, hyperaesthesia, paraesthesia, somnolence, warm sensation. Palpitations. Asthenia; heaviness, tightness, pain or pressure in throat, neck, limbs or chest.
Drug Interactions
Avoid concomitant administration of other 5HT1B/1D agonists w/in 24 hr. Possible increased risk of coronary vasospasm w/ ergotamine. Increased AUC w/ MAO-A inhibitors eg, moclobemide; cimetidine; fluvoxamine, quinolones eg, ciprofloxacin; St. John's wort.
ATC Classification
N02CC03 - zolmitriptan ; Belongs to the class of selective serotonin (5HT1) agonists preparations. Used to relieve migraine.
Zomig tab 2.5 mg
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