Acetazolamide


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity to sulfonamides. Na and/or K depletion, suprarenal gland failure, hyperchloraemic acidosis, hepatic cirrhosis, adrenocortical insufficiency, long term use in chronic non-congestive angle-closure glaucoma. Severe renal and hepatic impairment.
Special Precautions
Patients with diabetes mellitus, respiratory acidosis, impaired alveolar ventilation (e.g. pulmonary obstruction, emphysema), potential urinary tract obstruction, history of renal calculi. Concomitant use with high-dose aspirin. Mild to moderate renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness and myopia, if affected, do not drive or operate machinery. Monitoring Parameters Monitor CBC with differential, serum electrolytes and IOP at baseline and periodically thereafter; growth (children). Assess for allergy history prior to treatment initiation. Monitor for signs of suicidal ideation and behaviour; signs of excessive dosing and acidosis especially in elderly.
Adverse Reactions
Significant: Metabolic acidosis, electrolyte imbalance (e.g. hypokalaemia, hyponatraemia), impaired mental alertness and physical coordination, suicidal ideation and behaviour, growth retardation (children in long-term therapy), acute generalised exanthematous pustulosis. Ear and labyrinth disorders: Tinnitus, impaired hearing. Eye disorders: Transient myopia. Gastrointestinal disorders: Nausea, vomiting, diarrhoea. General disorders and administration site conditions: Fever, malaise, fatigue, ataxia, inj site pain. Hepatobiliary disorders: Abnormal liver function, hepatitis, cholestatic jaundice. Metabolism and nutrition disorders: Thirst, hyperglycaemia, hypoglycaemia. Nervous system disorders: Headache, paraesthesia, dysgeusia, flaccid paralysis. Psychiatric disorders: Irritability, depression, excitement, anorexia, confusion. Renal and urinary disorders: Polyuria, haematuria, glycosuria, crystalluria, renal calculi, colic or lesion; renal failure. Reproductive system and breast disorders: Decreased libido. Skin and subcutaneous tissue disorders: Rash, urticaria, photosensitivity. Vascular disorders: Flushing.
Potentially Fatal: Rarely, severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, aplastic anaemia, blood dyscrasias, fulminant hepatic necrosis and anaphylaxis.
Drug Interactions
May increase serum levels of anticonvulsants (e.g. phenytoin, carbamazepine). May potentiate the effects of folic acid antagonists, hypoglycaemics, and oral anticoagulants. May require dose adjustments when co-administered with cardiac glycosides or hypertensive agents. May increase excretion of lithium. May reduce serum level of primidone. May enhance effects of amphetamines and quinidine. May prevent the urinary antiseptic effect of methenamine. May elevate serum ciclosporin levels. Increased risk of renal calculus formation with Na bicarbonate.
ATC Classification
S01EC01 - acetazolamide ; Belongs to the class of carbonic anhydrase inhibitors. Used in the treatment of glaucoma.
Disclaimer: This information is independently developed by CIMS based on acetazolamide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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