Generic Medicine Info
Effervescent tab: Should be taken with food. Dissolve in 1/2 glass of water before taking.
For mucolytic use (oral): Children <2 years.
Special Precautions
Patient with asthma, history of bronchospasm, atopy; decreased cough reflex (e.g. frail patient), predisposition to gastrointestinal haemorrhage [e.g. oesophageal varices, peptic ulcer] (oral). Patient requiring fluid restriction or who weighs ≤40 kg (IV). Acetylcysteine is available in multiple dosage forms, refer to detailed product guidelines for specific recommendations. Children. Pregnancy and lactation. Patient Counselling Ophthalmic: This drug may cause blurred vision after use, if affected, do not drive or operate machinery. Remove contact lenses before administration and allow a 15-minute interval before reinserting lenses. Monitoring Parameters Monitor pulmonary function and response to treatment. For paracetamol poisoning: Monitor serum paracetamol concentrations, AST, ALT, bilirubin, prothrombin time, INR, serum creatinine, BUN, serum glucose, Hb, haematocrit, and electrolytes; re-assess LFTs 4-6 hourly for possible hepatotoxicity. Observe for anaphylactoid reactions (particularly with IV use).
Adverse Reactions
Significant: Increased risk of upper gastrointestinal haemorrhage (oral), small increase in prothrombin time (IV). Rarely, bronchospasm; serious skin reactions (e.g. Stevens-Johnson syndrome, Lyell's syndrome), generalised urticaria (oral). Blood and lymphatic system disorders: Thrombocytopenia (IV). Cardiac disorders: Tachycardia; cardiac arrest (IV). Ear and labyrinth disorders: Tinnitus (oral). Eye disorders: Eye irritation, pain or swelling, blurred vision. Gastrointestinal disorders: Nausea, vomiting, stomatitis; diarrhoea, abdominal pain (oral). General disorders and administration site conditions: Pyrexia, chest tightness; malaise, facial pain (IV). Metabolism and nutrition disorders: Acidosis (IV). Musculoskeletal and connective tissue disorders: Arthralgia, arthropathy (IV). Nervous system disorders: Headache (oral); drowsiness (inhalation/endotracheal). Psychiatric disorders: Anxiety (IV). Respiratory, thoracic and mediastinal disorders: Rhinorrhoea; throat tightness, pharyngitis, rhonchi, cough, stridor (IV); tracheal and bronchial tracts irritation (inhalation/endotracheal). Skin and subcutaneous tissue disorders: Pruritus, rash, angioedema; exanthema (oral); hyperhidrosis (IV). Vascular disorders: Hypotension; flushing, vasodilation, syncope, cyanosis (IV).
Potentially Fatal: Fluid overload resulting in hyponatraemia and seizures (IV). Rarely, anaphylactoid reactions (particularly with IV use).
Drug Interactions
Concomitant use with antitussives may lead to a build-up of secretions due to suppressed cough reflex; avoid concurrent use. May increase the vasodilatory and platelet aggregation-inhibiting effect of glyceryl trinitrate.
CIMS Class
Antidotes, Detoxifying Agents & Drugs Used in Substance Dependence / Cough & Cold Preparations / Other Eye Preparations
ATC Classification
S01XA08 - acetylcysteine ; Belongs to the class of other ophthalmologicals.
V03AB23 - acetylcysteine ; Belongs to the class of antidotes. Used to neutralize paracetamol overdose.
R05CB01 - acetylcysteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Disclaimer: This information is independently developed by CIMS based on acetylcysteine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 CIMS. All rights reserved. Powered by
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