Adefovir


Generic Medicine Info
Administration
Adefovir: May be taken with or without food.
Contraindications
Hypersensitivity. Lactation.
Special Precautions
Patient w/ hepatomegaly or other risk factors for liver disease. Renal impairment. Pregnancy. Monitoring Parameters Hepatitis B biochemical, virological and serological markers should be monitored 6 mthly. Monitor renal function 3 mthly, hepatic function for several mth following discontinuation. Determine HIV status prior to treatment.
Adverse Reactions
Nephrotoxicity (chronic use); GI effects (e.g. nausea, flatulence, diarrhoea, dyspepsia, vomiting, abdominal pain, pancreatitis), headache, asthenia, pruritus, skin rash, proximal renal tubulopathy, Fanconi syndrome, hypophosphatemia, raised liver enzymes and serum creatinine concentrations, renal failure, renal insufficiency, myopathy, osteomalacia.
Potentially Fatal: Lactic acidosis, severe hepatomegaly w/ steatosis.
Drug Interactions
May diminish the therapeutic effect of tenofovir. Increased risk of nephrotoxicity w/ other nephrotoxic drugs (e.g. aminoglycosides, ciclosporin, tacrolimus, vancomyicn, certain NSAIDs).
CIMS Class
Disclaimer: This information is independently developed by CIMS based on adefovir from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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