Manage Account
Change Password
Sign Out
UserName
Profession Email
Profession Email
|
Dosage/Direction for Use
Oral As an antacid Adult: Doses of up to 1 g, given after meals and at bedtime. Oral Hyperphosphataemia in patients with chronic renal failure Adult: Up to 10 g daily in divided doses, adjusted to individual patient's requirement. Topical/Cutaneous As a skin protectant Adult: As 0.275% gel: Clean and dry affected area thoroughly then apply as needed or as directed. |
|
Administration
May be taken with or without food.
|
|
Contraindications
Hypophosphataemia, acute porphyria.
|
|
Special Precautions
Patient w/ restricted phosphate intake, low Na diet, uraemia, heart failure, oedema, recent GI haemorrhage. Hepatic (e.g. cirrhosis) and renal (e.g. chronic renal failure) impairment. Pregnancy. Patient Counselling Avoid application over deep and puncture wounds, infected areas, or lacerations. Monitoring Parameters Monitor serum Ca and phosphate levels regularly when patient is on chronic therapy.
|
|
Adverse Reactions
Constipation, intestinal obstruction, faecal discolouration and impaction, nausea, vomiting, stomach cramps; hypomagnesaemia, hypophosphataemia.
|
|
Overdosage
Symptoms: Phosphate depletion, (manifested in muscle weakness, anorexia, malaise) which may lead to osteomalacia, osteoporosis, or urinary calculi. Management: Employ gastric lavage, and if necessary, followed by a mild aperient.
|
|
Drug Interactions
May interfere w/ the absorption of some drugs including tetracyclines, penicillin, sulfonamides, Fe, digoxin, indometacin, naproxen, phenylbutazone, quinidine and vit. Absorption is enhanced by citrates or ascorbic acid.
|
|
Food Interaction
Prolonged availability and increased concentration w/ food.
|
|
Action
Aluminium hydroxide neutralises HCl in the stomach resulting in increased gastric pH and inhibition of pepsin activity. Additionally, it reduces absorption of phosphate by binding and forming insoluble complexes in the GI tract.
Duration: 20-60 min (fasting); up to 3 hr (after meal). Absorption: Slowly converted to Al chloride which is absorbed from the GI tract. Excretion: Via urine (17-30%) and faeces (as insoluble Al salts formed in the intestines). |
|
Storage
Oral: Store below 30°C. Topical/Cutaneous: Store below 30°C.
|
|
CIMS Class
|
|
ATC Classification
A02AB01 - aluminium hydroxide ; Belongs to the class of aluminium-containing antacids.
|
