Aluminium hydroxide


Full Generic Medicine Info
Dosage/Direction for Use

Oral
As an antacid
Adult: Doses of up to 1 g, given after meals and at bedtime.

Oral
Hyperphosphataemia in patients with chronic renal failure
Adult: Up to 10 g daily in divided doses, adjusted to individual patient's requirement.

Topical/Cutaneous
As a skin protectant
Adult: As 0.275% gel: Clean and dry affected area thoroughly then apply as needed or as directed.
Administration
May be taken with or without food.
Contraindications
Hypophosphataemia, acute porphyria.
Special Precautions
Patient w/ restricted phosphate intake, low Na diet, uraemia, heart failure, oedema, recent GI haemorrhage. Hepatic (e.g. cirrhosis) and renal (e.g. chronic renal failure) impairment. Pregnancy. Patient Counselling Avoid application over deep and puncture wounds, infected areas, or lacerations. Monitoring Parameters Monitor serum Ca and phosphate levels regularly when patient is on chronic therapy.
Adverse Reactions
Constipation, intestinal obstruction, faecal discolouration and impaction, nausea, vomiting, stomach cramps; hypomagnesaemia, hypophosphataemia.
Overdosage
Symptoms: Phosphate depletion, (manifested in muscle weakness, anorexia, malaise) which may lead to osteomalacia, osteoporosis, or urinary calculi. Management: Employ gastric lavage, and if necessary, followed by a mild aperient.
Drug Interactions
May interfere w/ the absorption of some drugs including tetracyclines, penicillin, sulfonamides, Fe, digoxin, indometacin, naproxen, phenylbutazone, quinidine and vit. Absorption is enhanced by citrates or ascorbic acid.
Food Interaction
Prolonged availability and increased concentration w/ food.
Action
Aluminium hydroxide neutralises HCl in the stomach resulting in increased gastric pH and inhibition of pepsin activity. Additionally, it reduces absorption of phosphate by binding and forming insoluble complexes in the GI tract.
Duration: 20-60 min (fasting); up to 3 hr (after meal).
Absorption: Slowly converted to Al chloride which is absorbed from the GI tract.
Excretion: Via urine (17-30%) and faeces (as insoluble Al salts formed in the intestines).
Storage
Oral: Store below 30°C. Topical/Cutaneous: Store below 30°C.
ATC Classification
A02AB01 - aluminium hydroxide ; Belongs to the class of aluminium-containing antacids.
Disclaimer: This information is independently developed by CIMS based on aluminium hydroxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
MORE
LESS
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in