Amantadine


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity to amantadine. History of epilepsy or other seizure disorders, history of gastric ulceration. Severe renal impairment (CrCl <15 mL/min). Lactation.
Special Precautions
Patient w/ or history of CV disease, recurrent eczema, psychiatric disorders, untreated angle-closure glaucoma. Avoid abrupt withdrawal. Hepatic and mild to moderate renal impairment. Childn, elderly. Pregnancy. Patient Counselling This drug may cause dizziness, blurred vision or impair alertness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor renal function, BP, Parkinson's or influenza symptoms, mental status.
Adverse Reactions
Livedo reticularis, headache, dizziness, insomnia, anxiety, nightmares, inability to concentrate, mood changes, psychotic reactions, hallucinations, confusion, palpitations, orthostatic hypotension, slurred speech, ataxia, anorexia, lethargy, nausea, vomiting, dry mouth, constipation, rash, diaphoresis, blurred vision, CHF, dyskinesia, convulsions, dyspnoea. Rarely, acute resp failure, pulmonary oedema, tachypnea, urinary retention, urinary incontinence, diarrhoea, photosensitisation, exanthema, leucopenia, neutropenia, oculogyric episodes.
Potentially Fatal: Suicide attempts and suicidal ideation; neuroleptic malignant syndrome (in association w/ dose reduction or withdrawal).
Drug Interactions
Increased risk of confusion, hallucinations, nightmares, GI disturbances or other atropine-like side effects w/ anticholinergic agents or levodopa. Psychotic symptoms may worsen w/ concomitant neuroleptic medication. Additive CNS toxicity w/ drugs acting on CNS. Reduced renal clearance w/ quinine or quinidine.
ATC Classification
N04BB01 - amantadine ; Belongs to the class of adamantine derivative dopaminergic agents. Used in the management of Parkinson's disease.
Disclaimer: This information is independently developed by CIMS based on amantadine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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