Aminocaproic acid


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Treatment and prophylaxis of haemorrhage due to hyperfibrinolysis Initial: 4-5 g, followed by 1-1.25 g hrly for up to 8 hr. Max: 24 g/day. Patients w/ haemophilia undergoing dental extraction 50-100 mg/kg 4-6 hrly started before the procedure up to 7-10 days. Max: 24 g/day. IV Treatment and prophylaxis of haemorrhage due to hyperfibrinolysis As 2% soln: Initial: 4-5 g over 1 hr, followed by continuous infusion of 1 g/hr for up to 8 hr. Max: 24 g/day.
Administration
May be taken with or without food. May be taken w/ meals to prevent GI upset.
Contraindications
Active intravascular clotting process, disseminated intravascular coagulation (w/o heparin). Concomitant use w/ factor IX complex and anti-inhibitor coagulant complex.
Special Precautions
Patient w/ cardiac disease, haematuria of upper urinary tract, uraemia. Admin by rapid IV inj of undiluted soln. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor creatine phosphokinase (CPK) for signs of muscle damage esp in patients receiving long-term therapy. Monitor for fibrinogen, fibrin split products, BUN, and creatinine.
Adverse Reactions
Headache, oedema, tinnitus, nasal and conjunctival congestion, malaise; anaphylaxis, rash; thrombosis; hypotension, bradycardia, peripheral ischaemia; abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leucopenia, thrombocytopenia; increased CPK, muscle weakness, myalgia, myopathy, myositis, rhabdomyolysis; increase BUN, confusion, convulsions, delirium, dizziness, hallucinations, intracranial HTN, stroke, syncope, dyspnoea, pulmonary embolism, pruritus; decreased vision, watery eyes, cardiac and hepatic damage, renal failure.
Drug Interactions
Enhanced thrombogenic effect w/ oral tretinoin. May increase risk of thrombosis w/ fibrinogen concentrate.
CIMS Class
ATC Classification
B02AA01 - aminocaproic acid ; Belongs to the class of amino acid antifibrinolytics. Used in the treatment of hemorrhage.
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