Amisulpride


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Acute psychosis
Adult: 400-800 mg bid. Max: 1.2 g daily. Patients w/ predominantly negative symptoms: 50-300 mg daily.
Renal impairment:
CrCl (ml/min)Dosage Recommendation
10-30One-third of the usual dose.
31-60Half the usual dose.
Administration
Should be taken on an empty stomach. Preferably taken before meals.
Contraindications
Phaeochromocytoma, concomitant prolactin-dependent tumours (e.g. pituitary gland prolactinomas or breast cancer). Pre-pubertal childn. Combination w/ levodopa.
Special Precautions
Patient w/ history of epilepsy; Parkinson's disease, CV disease. Avoid abrupt withdrawal. Renal impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause somnolence, if affected, may impair ability to drive or operate machinery.
Adverse Reactions
Insomnia, anxiety, agitation, drowsiness, wt gain, acute dystonia, parkinsonism, akathisia, tardive dyskinesia, QT prolongation, hypotension, bradycardia, GI disorders (e.g. constipation, nausea, vomiting, dry mouth), hyperglycaemia; breast pain, erectile dysfunction, amenorrhoea, gynaecomastia, galactorrhoea. Rarely, allergic reactions, abnormal LFTs, seizures.
Potentially Fatal: Neuroleptic malignant syndrome.
Overdosage
Symptoms: Generalised convulsions, coma, motor restlessness, tachycardia, slight prolongation of the QT interval, drowsiness, sedation, hypotension, extrapyramidal symptoms. Management: Symptomatic and supportive treatment. Institute close supervision of vital functions including continuous cardiac monitoring until patient recovers. Perform gastric lavage. In case severe extrapyramidal symptoms occur, administer anticholinergic agents.
Drug Interactions
Increased risk of arrhythmias w/ cisapride, thioridazine, halofantrine, erythromycin, some antiarrhythmics, pimozide, haloperidol, TCAs, β-blockers, some Ca channel blockers, clonidine, guanfacine, digoxin, K-depleting diuretics, lithium, antimalarials. May enhance effects of antihypertensives and CNS depressants (e.g. sedative H1-antihistamines, narcotics, anaesth, analgesics, barbiturates, benzodiazepines, other anxiolytics, clonidine and derivatives).
Potentially Fatal: Reciprocal antagonism between levodopa and neuroleptics.
Food Interaction
May enhance central effects of alcohol.
Action
Amisulpride is a substituted benzamide atypical antipsychotic which binds selectively w/ a high affinity to human dopaminergic D2 and D3 receptor subtypes.
Absorption: Absorbed from GI tract. Bioavailability: Approx 48%. Time to peak plasma concentration: 1 hr (initial); 3-4 hr (2nd).
Distribution: Volume of distribution: 5.8 L/kg. Plasma protein binding: Approx 16%.
Metabolism: Limited metabolism.
Excretion: Mainly via urine as unchanged drug. Terminal elimination half-life: Approx 12 hr.
Storage
Oral: Store below 25°C.
CIMS Class
ATC Classification
N05AL05 - amisulpride ; Belongs to the class of benzamides antipsychotics.
Disclaimer: This information is independently developed by CIMS based on amisulpride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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