Amlodipine + enalapril


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Refractory HTN Per tab contains amlodipine besylate 5 mg and enalapril maleate 5 mg: Start w/ 1 tab daily, increase gradually if needed.
Contraindications
Hypersensitivity to either component. History of angioedema related to previous exposure to ACE inhibitor. Pregnancy.
Special Precautions
Lactation. Renal and hepatic disease, congestive heart failure; concomitant K supplements & potassium-conserving diuretics, hypovolaemic shock, diuretic therapy; periodic blood count monitoring to preclude neutropaenia or agranulocytosis.
Adverse Reactions
Angioneurotic oedema, nausea, headache, cough, dizziness, fatigue, palpitations, chest pain, flushing, rash; increases in BUN, serum K & creatinine levels may occur; neutropaenia.
Potentially Fatal: NA.
Drug Interactions
Indometacin and other NSAIDs may blunt antihypertensive effect. Diuretics enhance antihypertensive effect.
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
C09AA02 - enalapril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Disclaimer: This information is independently developed by CIMS based on amlodipine + enalapril from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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