Amoxicillin + carbocisteine

Full Generic Medicine Info
Dosage/Direction for Use

Respiratory tract infections associated with excessive and/or viscous mucus
Adult: Each capsule contains amoxicillin 250/500 mg and carbocisteine 150 mg: 1 or 2 cap tid.
Allergy to penicillins, pregnancy.
Special Precautions
History of peptic ulcer, severe renal impairment. Infectious mononucleosis and lactation.
Adverse Reactions
Headache, nausea, dizziness, vomiting, diarrhoea, GI discomfort/ bleeding, black hairy tongue, maculopapular rash, urticaria, eosinophilia, hemolytic anemia, thrombocytopenia.
Potentially Fatal: Anaphylaxis, pseudomembranous colitis, acute cytoloytic hepatitis and Stevens-Johnson syndrome.
Drug Interactions
Live oral typhoid vaccine should not be given 3 days before or 3 days after amoxicillin admin as immune response may be attenuated. Amoxicillin increases the anticoagulant response of coumarins. Amoxicillin may reduce OC pill absorption leading to breakthrough bleeding or pregnancy. Amoxicillin reduces the renal clearance of methotrexate and pemetrexate. Amoxicillin level significantly reduced when given with or 2 hr after acacia admin.
Food Interaction
Tannins in catha reduced amoxicillin absorption if amoxicillin is admin <2 hr after chewing catha.
Lab Interference
Possible interference with urinary glucose tests using cupric sulfate. May increase degradation of aminoglycosides in vitro. Increase in ALT and AST.
Amoxicillin inhibits the final transpeptidation of peptidoglycan synthesis in bacterial cell walls. Hence, cell wall synthesis is inhibited and results in bacterial lysis. Carbocisteine is a mucolytic. It penetrates into lung tissue and respiratory mucus. Reduces viscosity of bronchial secretions and allows greater penetration of antibacterial drug. Expectoration of the mucus is facilitated.
Absorption: Amoxicillin: Rapidly and almost completely absorbed from the GI tract; peak plasma concentration (oral): 1-2 hr. Carbocisteine: Rapidly and well absorbed from GI tract; peak plasma concentration (oral): 2 hr.
Distribution: Amoxicillin: Protein binding: 17-20 %; Widely distributed to body fluid and bone, CSF (small concentrations except when meninges are inflamed). Carbocisteine: Lungs.
Metabolism: Amoxicillin: Partially metabolised to penicilloic acid. Carbocisteine: Metabolised via acetylation, decarboxylation and sulfoxidation.
Excretion: Amoxicillin: Via urine: 60% as unchanged drug. Elimination half-life: Adults: 0.7-1.4hr, CrCl<10 ml/min: 7-21 hr; infants & children: 1-2 hr. Carbocisteine: Via urine: Unchanged and as metabolites.
CIMS Class
ATC Classification
R05CB03 - carbocisteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on amoxicillin + carbocisteine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 CIMS. All rights reserved. Powered by
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