Amoxicillin + clavulanic acid


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Ear, nose and/or throat infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Genitourinary infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Intra-abdominal infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Skin and soft tissue infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Pyelonephritis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Cystitis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Infected animal bites
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Acute bacterial sinusitis
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Upper respiratory tract infections
Adult: Available preparations: Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 250 mg/125 mg tid, or 500 mg/125 mg tid, or 875 mg/125 mg bid. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review. For treatment of acute bacterial sinusitis only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For sinusitis: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 250 mg and clavulanic acid 125 mg conventional tab ≥40 kg: Same as adult dose. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of acute bacterial sinusitis only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis patients: Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 500 mg/250 mg 24 hourly, then 500 mg/250 mg dose during and repeated at the end of dialysis; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg during and repeated at the end of dialysis. Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg prior to and after dialysis. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg once daily; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg onc
10-30Adults and children ≥40 kg: As 250 mg/125 mg conventional tab: 250 mg/125 mg bid; As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Child
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Osteomyelitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Lower respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Bone and joint infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Community-acquired pneumonia
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Acute exacerbations of chronic bronchitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Oral
Acute otitis media
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab Amoxicillin 875 mg and clavulanic acid 125 mg conventional tab Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. As conventional tab: 500 mg/125 mg tid, or 875 mg/125 mg 2 or 3 times daily. As oral susp: 500 mg/125 mg tid. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. For treatment of community-acquired pneumonia only: As extended-release tab: 2,000 mg/125 mg 12 hourly for 7-10 days.
Child: Available preparations: Amoxicillin 125 mg and clavulanic acid 31.25 mg per 5 mL oral susp Amoxicillin 250 mg and clavulanic acid 62.5 mg per 5 mL oral susp ≤6 years <40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 400 mg and clavulanic acid 57 mg per 5 mL oral susp ≤6 years <40 kg: 25 mg/3.6 mg/kg daily to 45 mg/6.4 mg/kg daily given in 2 divided doses. For otitis media and lower respiratory tract infections: Up to 70 mg/10 mg/kg daily may be given in 2 divided doses. Amoxicillin 500 mg and clavulanic acid 125 mg conventional tab 25-<40 kg: 20 mg/5 mg/kg daily to 60 mg/15 mg/kg daily given in 3 divided doses; ≥40 kg: Same as adult dose. Amoxicillin 1,000 mg and clavulanic acid 62.5 mg extended-release tab For treatment of community-acquired pneumonia only: ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg 24 hourly, then 500 mg/125 mg dose during and repeated at the end of dialysis; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg once daily. Give 15 mg/3.75 mg/kg dose prior to and after dialysis. CrCl <10 mL/min: Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 15 mg/3.75 mg/kg given as single daily dose. Max: 500 mg/125 mg daily. As extended-release tab: Contraindicated.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg once daily; Children <40 kg: As 500 mg/125 mg conventional ta
10-30Adults and children ≥40 kg: As 500 mg/125 mg conventional tab, 125 mg/31.25 mg and 250 mg/62.5 mg per 5 mL oral susp: 500 mg/125 mg bid; Children <40 kg: As 500 mg/125 mg conventional tab, 125
<30As extended-release tab: Contraindicated.

Reconstitution: Powder for oral susp: Reconstitute with the appropriate volume of water as indicated on the label. Invert and shake well until suspended.

Intravenous
Acute exacerbations of chronic bronchitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Community-acquired pneumonia
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Bone and joint infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Intra-abdominal infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Genitourinary infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Ear, nose and/or throat infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Lower respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Osteomyelitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Pyelonephritis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Skin and soft tissue infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Upper respiratory tract infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Infected animal bites
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Cystitis
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. 1,000 mg/200 mg 8 hourly via slow inj over 3-4 minutes or via drip or infusion over 30-40 minutes. In more serious infections, frequency may be increased to 6 hourly intervals. Treatment duration: Up to 14 days without review; osteomyelitis may require longer periods of treatment. Consider local guidelines on appropriate dosing frequencies and recommendations.
Child: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion <3 months or weighing <4 kg: 25 mg/5 mg/kg 12 hourly via infusion only over 30-40 minutes; ≥3 months <40 kg: 25 mg/5 mg/kg 8 hourly via slow IV inj over 3-4 minutes or via drip or infusion over 30-40 minutes; ≥40 kg: Same as adult dose.
Renal impairment: Haemodialysis: Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly, then 500 mg/100 mg dose at the end of dialysis; Children <40 kg: 25 mg/5 mg/kg 24 hourly, then 12.5 mg/2.5 mg/kg dose at the end of dialysis.
CrCl (ml/min)Dosage Recommendation
<10Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 24 hourly; Children <40 kg: 25 mg/5 mg/kg 24 hourly.
10-30Adults and children ≥40 kg: Initially, 1,000 mg/200 mg via slow inj or infusion, followed by 500 mg/100 mg 12 hourly; Children <40 kg: 25 mg/5 mg/kg 12 hourly.

Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.

Intravenous
Prophylaxis of surgical infections
Adult: Available preparations: Amoxicillin 500 mg and clavulanic acid 100 mg powder for solution for inj or infusion Amoxicillin 1,000 mg and clavulanic acid 200 mg powder for solution for inj or infusion In major surgical procedures involving the head and neck, cardiac, gastrointestinal tract, biliary tract, renal, joint replacement, and pelvic cavity: For procedures <1 hour duration: 1,000 mg/200 mg to 2,000 mg/200 mg given at induction of anaesthesia; For procedures >1 hour duration: 1,000 mg/200 mg to 2,000 mg/200 mg given at induction of anaesthesia, then up to 3 more 1,000 mg/500 mg doses in 24 hours. Administer normal IV or oral treatment course post-operatively, if clear signs of infection at operation is observed.
Reconstitution: Powder for solution for IV inj: Dissolve vial labelled as 500 mg/100 mg and 1,000 mg/200 mg with 10 mL and 20 mL of water for inj to yield approx 10.5 mL and approx 20.9 mL reconstituted solution, respectively. Powder for solution for IV infusion: Add the 500 mg/100 mg and 1,000 mg/200 mg reconstituted solution to 50 mL and 100 mL of infusion fluid (e.g. water for inj, 0.9% NaCl inj), respectively. IV reconstituted solutions should be administered or diluted for infusion within 20 minutes. Refer to detailed product guideline for further appropriate infusion fluids and their stability.
Incompatibility: Powder for solution for inj or infusion: Incompatible with blood products, other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions, aminoglycosides, and infusions containing glucose, dextran, or bicarbonate.
Contraindications
Hypersensitivity or history of hypersensitivity reactions (e.g. anaphylaxis, Stevens-Johnson syndrome) to amoxicillin, clavulanic acid, or other β-lactam antibacterials (e.g. penicillin, cephalosporin, carbapenem, monobactam). History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid treatment. As extended-release tab: Severe renal impairment (CrCl <30 mL/min) and patients on haemodialysis.
Special Precautions
Patients with infectious mononucleosis; reduced urine output. Atopic individuals. Renal (including haemodialysis patients) and hepatic impairment. Children. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, convulsions, and allergic reactions, if affected, do not drive or operate machinery. Do not switch between different formulations unless instructed by your doctor. Monitoring Parameters Perform culture and sensitivity tests. Monitor CBC with differential, renal function tests, and LFTs periodically especially with prolonged treatment; LFTs at regular intervals in patients with hepatic impairment. Assess for signs of infection at baseline and throughout the treatment; anaphylaxis during 1st dose.
Adverse Reactions
Significant: Diarrhoea, fungal or bacterial superinfection, convulsions (at high doses or in patients with renal impairment), morbilliform rash (in patients with mononucleosis). Rarely, crystalluria (IV), prothrombin time prolongation. Blood and lymphatic system disorders: Haemolytic anaemia, reversible agranulocytosis. Rarely, thrombocytopenia, reversible leucopenia or neutropenia. Gastrointestinal disorders: Nausea, vomiting, indigestion, black hairy tongue. Immune system disorders: Serum sickness-like syndrome, urticaria, hypersensitivity vasculitis. Infections and infestations: Mucocutaneous candidosis. Investigations: Increased AST/ALT. Nervous system disorders: Headache, dizziness, reversible hyperactivity. Renal and urinary disorders: Interstitial nephritis. Reproductive system and breast disorders: Vaginal mycosis. Skin and subcutaneous tissue disorders: Rash, pruritus, Stevens-Johnson syndrome. Rarely, erythema multiforme.
Potentially Fatal: Severe hypersensitivity reactions, including anaphylactoid and severe cutaneous reactions (e.g. acute generalised exanthematous pustulosis); Clostridium difficile-associated diarrhoea or pseudomembranous colitis. Rarely, hepatic dysfunction (e.g. cholestatic jaundice, hepatitis).
Overdosage
Symptoms: Gastrointestinal effects (e.g. stomach or abdominal pain, vomiting, and diarrhoea), rash, hyperactivity, drowsiness, fluid and electrolyte imbalance, crystalluria resulting in renal failure, and convulsions (in patients with renal impairment). Management: Symptomatic and supportive treatment. Focus on water/electrolyte balance.
Drug Interactions
Reduced pre-dose concentrations of mycophenolate mofetil active metabolite. May reduce the efficacy of combined oral oestrogen/progesterone contraceptives. Amoxicillin: Increased risk of allergic skin reactions with allopurinol. Probenecid increases and prolongs plasma concentrations of amoxicillin. May increase INR in patients maintained with oral anticoagulants (e.g. acenocoumarol, warfarin). May reduce the excretion and increase the risk of methotrexate toxicity.
Food Interaction
Increased amoxicillin absorption and decreased gastrointestinal upset with food. Decreased clavulanic acid absorption with high-fat meals.
Lab Interference
May cause false-positive result for Platelia Aspergillus EIA test. Amoxicillin: Non-enzymatic methods for urinary glucose testing (e.g. Benedict's solution, Fehling's solution) may lead to false-positive reactions. May transiently decrease plasma levels of total conjugated oestriol, oestriol-glucuronide, conjugated oestrone, and oestradiol in pregnant women. Clavulanic acid: May result in false-positive Coombs test.
Action
Amoxicillin, a semi-synthetic penicillin, inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs), thereby blocking the final transpeptidation step of peptidoglycan synthesis in the bacterial cell walls. It is susceptible to degradation by β-lactamases which are produced by certain resistant bacteria. Clavulanic acid, a β-lactam structurally related to penicillin, binds and inhibits β-lactamases, thereby preventing amoxicillin inactivation and expands the amoxicillin spectrum of activity. It does not exert clinically significant antibacterial effect alone. Synonym: Co-amoxiclav
Absorption: Amoxicillin: Rapidly and well absorbed from the gastrointestinal tract. Increased absorption and decreased gastrointestinal upset with food. Bioavailability: Approx 70%. Time to peak plasma concentration: Approx 1-2 hours. Clavulanic acid: Rapidly and well absorbed from the gastrointestinal tract. Decreased absorption with high-fat meals. Bioavailability: Approx 70%. Time to peak plasma concentration: 1.5 hours.
Distribution: Amoxicillin: IV: Readily distributed into body tissues and fluids (e.g. gall bladder, abdominal or muscle tissues, skin, fat, synovial and peritoneal fluids, bile, pus) except the brain and CSF. Crosses placenta and enters breast milk. Volume of distribution: Approx 0.3-0.4 L/kg. Plasma protein binding: Approx 18%. Clavulanic acid: IV: Well distributed into body tissues and fluids (e.g. gall bladder, abdominal or muscle tissues, skin, fat, synovial and peritoneal fluids, bile, pus). Crosses placenta and enters breast milk. Volume of distribution: Approx 0.2 L/kg. Plasma protein binding: Approx 25%.
Metabolism: Amoxicillin: Metabolised to a limited extent to form inactive penicilloic acid. Clavulanic acid: Extensively metabolised.
Excretion: Amoxicillin: Mainly via urine (approx 60-80% as unchanged drug). Elimination half-life: Approx 1.3 hours. Clavulanic acid: Via urine (approx 25-40% as unchanged drug); faeces; expired air. Elimination half-life: Approx 1 hour.
Storage
Intravenous: Vial: May be stored either below 25°C, or between 2-8°C. Protect from moisture. Storage conditions may vary according to individual product or country of use. Do not freeze reconstituted IV solution. Oral: Tab/susp: Store below 25°C. Protect from moisture. Reconstituted oral susp: Store between 2-8°C. Do not freeze.
CIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on amoxicillin + clavulanic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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