Amoxicillin + cloxacillin


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Susceptible infections
Adult: Per capsule contains amoxicillin 250 mg and cloxacillin 250 mg: 2-4 caps tid.

Parenteral

Susceptible infections
Adult: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1-2 vials every 6-8 hr. Dose may be given via IM/IV.
Child: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1 mth-2 yr: 0.25-0.5 vial every 6-8 hr; 2-10 yr: 0.5-1 vial every 6-8 hr. Dose may be given via IM/IV.
Contraindications
Hypersensitivity to penicillins.
Special Precautions
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.
Adverse Reactions
GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use.
Potentially Fatal: Rarely anaphylactic shock; pseudomembranous colitis.
Drug Interactions
Failure of OC may occur, loss of potency of cloxacillin in soln. reported with erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, Vit.C, & polymyxin B sulphate. Products containing cloxacillin should not be added to IV lipids, blood products, protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracycline antagonise bactericidal effect of penicillins. Probenecid prolongs serum drug concentration; Sulfonamides & aspirin inhibit serum protein binding of cloxacillin, thereby increasing serum-free drug levels.
Potentially Fatal: None reported.
Food Interaction
Food may delay cloxacillin absorption.
Lab Interference
Interferes with urinary test for Bence-Jones protein. Cloxacillin also interferes with urinary 17-oxosteroids measurements.
Action
Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens. Cloxacillin is a β-lactamase resistant penicillin active against gm+ve organisms including β-lactamase (penicillinase) producing strains of Staphylococci. It is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. Also effective against penicillinase producing gonococci and against N meningitidis and H influenzae.
CIMS Class
ATC Classification
J01CF02 - cloxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections.
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on amoxicillin + cloxacillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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