Manage Account
Change Password
Sign Out
UserName
Profession Email
Profession Email
|
Dosage/Direction for Use
Oral Susceptible infections Adult: Per capsule contains amoxicillin 250 mg and cloxacillin 250 mg: 2-4 caps tid. Parenteral Susceptible infections Adult: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1-2 vials every 6-8 hr. Dose may be given via IM/IV. Child: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1 mth-2 yr: 0.25-0.5 vial every 6-8 hr; 2-10 yr: 0.5-1 vial every 6-8 hr. Dose may be given via IM/IV. |
|
Contraindications
Hypersensitivity to penicillins.
|
|
Special Precautions
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.
|
|
Adverse Reactions
GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use.
Potentially Fatal: Rarely anaphylactic shock; pseudomembranous colitis. |
|
Drug Interactions
Failure of OC may occur, loss of potency of cloxacillin in soln. reported with erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, Vit.C, & polymyxin B sulphate. Products containing cloxacillin should not be added to IV lipids, blood products, protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracycline antagonise bactericidal effect of penicillins. Probenecid prolongs serum drug concentration; Sulfonamides & aspirin inhibit serum protein binding of cloxacillin, thereby increasing serum-free drug levels.
Potentially Fatal: None reported. |
|
Food Interaction
Food may delay cloxacillin absorption.
|
|
Lab Interference
Interferes with urinary test for Bence-Jones protein. Cloxacillin also interferes with urinary 17-oxosteroids measurements.
|
|
Action
Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens.
Cloxacillin is a β-lactamase resistant penicillin active against gm+ve organisms including β-lactamase (penicillinase) producing strains of Staphylococci. It is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. Also effective against penicillinase producing gonococci and against N meningitidis and H influenzae.
|
|
CIMS Class
|
|
ATC Classification
J01CF02 - cloxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections.
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections. |
