Amphotericin b


Generic Medicine Info
Contraindications
Hypersensitivity.
Special Precautions
Patient receiving leukocyte transfusion. Renal impairment. Pregnancy and Lactation. Lipid-based and conventional formulations should not be used interchangeably. Monitoring Parameters Monitor renal function frequently during therapy; BUN and serum creatinine every other day while tapering doses and weekly thereafter; electrolytes, primarily K, Mg; LFT, CBC, PT/PTT, temperature, input and output. Monitor for signs of hypokalaemia.
Adverse Reactions
Significant: Anaphylactic reactions, infusion reactions (e.g. fever, shaking, chills, hypotension. anorexia, nausea, vomiting, headache, and tachypnoea), leucoencephalopathy, anaemia, nephrotoxicity, myocardial toxicity, acute pulmonary toxicity. Blood and lymphatic system disorders: Leukocytosis, leucopenia, thrombocytopenia, hyperbilirubinaemia. Cardiac disorders: Chest pain, tachycardia, dyspnoea. Gastrointestinal disorders: Diarrhoea, epigastric pain, stomach cramps, constipation. Infections and infestations: Infection, sepsis. Injury, poisoning and procedural complications: Arachnoiditis, injection site pain, phlebitis. Investigations: Raised serum alkaline phosphatase, ALT, AST, creatinine, BUN. Metabolism and nutrition disorders: Peripheral oedema, oedema, hypokalaemia, hypomagnesaemia, hypocalcaemia, hyponatraemia, hypervolaemia. Musculoskeletal and connective tissue disorders: Back pain. Nervous system disorders: Neuralgia, paraesthesia. Psychiatric disorders: Delirium, insomnia, anxiety, confusion. Renal and urinary disorders: Azotaemia, renal tubular acidosis, nephrocalcinosis, urinary retention, haematuria. Respiratory, thoracic and mediastinal disorders: Cough. Skin and subcutaneous tissue disorders: Skin rash, pruritus. Vascular disorders: Flushing, hypertension.
Drug Interactions
May potentiate nephrotoxicity with nephrotoxic drugs (e.g. ciclosporin). Increased risk of hypotension, bronchospasm, and nephrotoxicity with antineoplastics. Increased risk of hypokalaemia with corticosteroids, corticotropin, loop and thiazide diuretics. May increase the toxicity of flucytosine and digitalis. May enhance the curariform effect of skeletal muscle relaxants (e.g. tubocurarine).
CIMS Class
Antifungals
ATC Classification
J02AA01 - amphotericin B ; Belongs to the class of antibiotics. Used in the systemic treatment of mycotic infections.
A01AB04 - amphotericin B ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
A07AA07 - amphotericin B ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
G01AA03 - amphotericin B ; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.
Disclaimer: This information is independently developed by CIMS based on amphotericin b from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in