Arsenic trioxide


Generic Medicine Info
Contraindications
Lactation.
Special Precautions
Patient w/ history of torsade de pointes, pre-existing QT interval prolongation, CHF, electrolyte abnormalities (e.g. hypokalaemia, hypomagnesaemia). Hepatic and renal impairment. Pregnancy. Monitoring Parameters Monitor ECG, blood sugar, electrolytes (esp K and Mg), CBC w/ differential, serum creatinine, hepatic function, and coagulation parameters at baseline then at least twice wkly during induction and at least wkly during consolidation (more frequent for clinically unstable patients).
Adverse Reactions
Leucocytosis, neutropenia, increased liver enzyme values, nausea, vomiting, diarrhoea, abdominal pain, fatigue, oedema, hyperglycaemia, hypokalaemia, dyspnoea, cough, rash, pruritus, pyrexia, headache, paraesthesia/dysesthesia, dizziness; haemorrhage, infection; atrial fibrillation/flutter.
Potentially Fatal: APL differentiation syndrome (i.e. fever, dyspnoea, wt gain, pulmonary infiltrates, pleural/pericardial effusions, w/ or w/o leucocytosis); QT prolongation leading to torsade de pointes, complete AV block.
Drug Interactions
Increased risk of hypokalaemia or hypomagnesaemia w/ diuretics and amphotericin B. Increased risk of QT prolongation w/ Class Ia/III antiarrhythmics (e.g. quinidine, amiodarone, sotalol, dofetilide), antipsychotics (e.g. thioridazine, ziprasidone, pimozide), antidepressants (e.g. amitriptyline), macrolides (e.g. erythromycin), antihistamines (e.g. terfenadine, astemizole), quinolones (e.g. sparfloxacin), and cisapride.
ATC Classification
L01XX27 - arsenic trioxide ; Belongs to the class of other antineoplastic agents. Used in the treatment of cancer.
Disclaimer: This information is independently developed by CIMS based on arsenic trioxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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