Asparaginase


Generic Medicine Info
Contraindications
History of serious pancreatitis, hypersensitivity, serious thrombotic (e.g. sagittal sinus thrombosis, pulmonary embolism) and haemorrhagic events related to asparaginase therapy. Lactation. Severe hepatic impairment (as colaspase).
Special Precautions
Patient w/ mild pancreatitis, hyperglycaemia. Hepatic impairment. Monitoring Parameters Monitor CBC w/ differential, amylase, lipase, insulin, triglycerides, blood glucose, and coagulation parameters. Perform LFT regularly. For colaspase, monitor trough serum asparaginase activity 3 days after admin.
Adverse Reactions
Hyperglycaemia, abnormal transaminase level, hyperbilirubinaemia, local reactions; nausea, vomiting, abdominal discomfort, diarrhoea; fever, rash, dyspnoea, bronchospasm, urticaria, hypotension, laryngeal oedema; altered blood lipids and cholesterol, hypoalbuminaemia, hyperammonaemia, uraemia, renal failure; drowsiness, depression, lethargy, confusion, dizziness, neurotoxicity, hallucination, seizure, Parkinson-like syndrome. Rarely, myalgia, reactive arthritis, transient bone-marrow depression, marked leucopenia.
Potentially Fatal: Serious hypersensitivity reactions (e.g. anaphylaxis), acute pancreatitis, hepatotoxicity, thrombosis, coagulopathy, ketoacidosis, hyperthermia.
Drug Interactions
Increased risk of anaphylaxis and neurotoxicity w/ vincristine. May increase the risk of coagulation abnormality w/ corticosteroid (e.g. prednisone). May diminish the effect on malignant cells of methotrexate. May increase serum concentration of dexamethasone.
ATC Classification
L01XX02 - asparaginase ; Belongs to the class of other antineoplastic agents. Used in the treatment of cancer.
Disclaimer: This information is independently developed by CIMS based on asparaginase from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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