Aspirin + ticlopidine


Full Generic Medicine Info
Dosage/Direction for Use

Oral
As an antithrombotic
Adult: Each tablet contains aspirin 100 mg and ticlopidine 250 mg: 1 tablet once daily.
Renal impairment:
CrCl (ml/min)Dosage Recommendation
<10Avoid use.
Hepatic impairment: Severe hepatic impairment: Avoid use.
Contraindications
Hypersensitivity to aspirin, NSAIDs or clopidogrel; active peptic ulceration; children<12 years ; patients with bleeding disorders or at increased risk of bleeding; severe renal or hepatic impairment; lactation.
Special Precautions
Pregnancy, history of peptic ulcer, bronchospasm, renal or hepatic impairment, elderly, children. Monitor alkaline phosphatase.
Adverse Reactions
Aspirin: GI disturbances, epigastric discomfort, prolonged bleeding time, rhinitis, urticaria; angioedema, salicylism. Ticlopidine: Increase in total cholesterol.
Potentially Fatal: Aspirin: Gastric erosion, ulceration, bleeding , thrombocytopenia; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yrs). Hepatotoxicity; CNS depression, which may lead to coma; CV collapse, resp failure; paroxysmal bronchospasm and dyspnoea. Ticlopidine: Intracranial bleeding, Stevens Johnson syndrome, thrombotic thrombocytopenic purpura.
Drug Interactions
Aspirin: Corticosteroids, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration. Use with anagrelide, argatroban, LMWH, bivalirudin, dasatinib, iloprost, lepirudin and tenecteplase may increase the risk of bleeding. Ticlopidine: Increases theophylline and possibly aminophylline levels. Increased risk of bleeding with abciximab, argatroban, bivalirudin, dasatinib, iloprost, LMWH, drotrecogin alfa, fondaparinux and gingko biloba. May increase bupropion level and side effects (light headedness, GI discomfort). Antacids decrease absorption of ticlopidine.
Potentially Fatal: Aspirin and ticlopidine: Risk of bleeding with dabigatran and coumarins. Ticlopidine: Increased risk of bleeding with phenindione. Increased risk of agranulocytosis with deferiprone.
Lab Interference
Aspirin: Interferes with thyroid function tests, urinary catecholamines, urine sugar, pregnancy tests and urine ketones.
Action
Aspirin inhibits platelet aggregation by its inhibitory effect on cyclo-oxygenase in thrombocytes. The anti-thrombotic action of ticlopidine is thought to be due to inhibition of ADP-mediated platelet aggregation. When used in combination, the anti-thrombotic effects of aspirin and ticlopidine are additive.
Absorption: Aspirin: Rapid oral absorption. Ticlopidine: Rapid and almost complete absorption.
Distribution: Aspirin: Widely distributed. Protein binding: 80-90%. Ticlopidine: Protein binding: 98%
Metabolism: Aspirin: Hydrolysed to salicylate in the gut wall; salicylate metabolised hepatically.Ticlopidine: Extensive hepatic metabolism to active metabolite.
Excretion: Aspirin: Via urine by glomerular filtration, active renal tubular secretion and passive tubular reabsorption; elimination half-life of parent drug:15-20 minutes. Ticlopidine: Via urine (60%) and faeces (25%); half-life 30-50 hr (terminal half-life).
ATC Classification
B01AC05 - ticlopidine ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Disclaimer: This information is independently developed by CIMS based on aspirin + ticlopidine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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