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Contraindications
Gastric or duodenal ulcers. Haemophilia, thrombocytopenia or other bleeding tendencies; patients receiving anti-coagulant treatment. Hypersensitivity to aspirin or other salicylates or ascorbic acid. Severe renal impairment.
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Special Precautions
Risk of Reye's syndrome in children with varicella infection or influenza-like illnesses. Not to be used for >10 days without medical advice. Treatment should be withdrawn 1 wk prior to surgery to prevent or reduce risk of bleeding complications. Caution when used in patients with impaired renal function, severe hepatic impairment, history of GI disorders e.g. peptic ulcers, ulcerative colitis and Crohn's disease, dyspepsia and when the patient is dehydrated. Pregnancy and lactation.
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Adverse Reactions
Dizziness, GI irritation e.g. dyspepsia, nausea, vomiting, erosion, ulceration, haematemesis and melaena. Prolonged use of high doses of aspirin may cause anaemia, blood dyscrasia, GI haemorrhage and peptic ulceration.
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Drug Interactions
Aspirin may increase hypoprothrombinemic effect of warfarin and other oral anticoagulants, thus increasing the risk of bleeding complications. May antagonise uricosuric effect of probenecid, phenylbutazone or sulfinpyrazone. Concurrent admin with corticosteroids may reduce the serum levels of aspirin. Aspirin may increase serum levels of methotrexate. Concurrent admin with alcohol increases risk and severity of GI bleeding and ulceration. Aspirin may reduce the absorption of vitamin C.
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CIMS Class
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ATC Classification
S01XA15 - ascorbic acid ; Belongs to the class of other ophthalmologicals.
G01AD03 - ascorbic acid ; Belongs to the class of organic acid antiinfectives. Used in the treatment of gynecological infections. |
