Atenolol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Hypertension 50-100 mg once daily, titrate dose based on patient response. Angina pectoris 50-100 mg daily given as a single dose or in divided doses. Intravenous Emergency treatment of cardiac arrhythmias 2.5 mg injected at a rate of 1 mg/minute, may repeat every 5 minutes if needed. Max: 10 mg. Alternatively, 0.15 mg/kg to be infused over 20 minutes. May repeat injection or infusion procedure every 12 hours as needed. Once control is achieved, maintain with oral doses of 50-100 mg daily. Acute myocardial infarction Within 12 hours of the onset of chest pain: Inject 5-10 mg slowly at a rate of 1 mg/minute, followed by an oral dose of 50 mg about 15 minutes later (if no adverse effects result from the injection). Alternatively, repeat IV dose of 5 mg 10 minutes after the initial dose followed by an oral dose of 50 mg 10 minutes after the last dose. A further oral dose of 50 mg may be given 12 hours after. Thereafter, maintain with 100 mg every 12 hours.
Administration
May be taken with or without food.
Contraindications
Patients with bradycardia, cardiogenic shock, hypotension, metabolic acidosis, 2nd or 3rd degree heart block, severe peripheral arterial disease, sick sinus syndrome (without pacemaker), uncompensated cardiac failure, and untreated phaeochromocytoma.
Special Precautions
Patients with bronchospasm or reversible obstructive airways disease, diabetes mellitus, peripheral vascular disease, Raynaud's disease, Prinzmetal's angina, myasthenia gravis, psoriasis and thyroid diseases. Avoid abrupt withdrawal. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor blood pressure, heart rate, ECG, and serum glucose (in patients with diabetes mellitus).
Adverse Reactions
Blood and lymphatic system disorders: Thrombocytopenia. Cardiac disorders: Bradycardia. Eye disorders: Dry eyes, visual disturbances. Gastrointestinal disorders: Nausea, diarrhoea, dry mouth. General disorders and administration site conditions: Fatigue. Musculoskeletal and connective tissue disorders: Lupus-like syndrome. Nervous system disorders: Dizziness, headache. Psychiatric disorders: Hallucinations, depression, nightmare, psychoses. Reproductive system and breast disorders: Impotence. Skin and subcutaneous tissue disorders: Psoriasiform skin reactions, purpura, alopecia. Vascular disorders: Postural hypotension, cold extremities, Raynaud's phenomenon.
Drug Interactions
Additive effects with Ca channel blockers (e.g. verapamil, diltiazem) and catecholamine-depleting agents (e.g. reserpine). May increase atrioventricular conduction time with digitalis glycosides. May aggravate rebound hypertension following clonidine withdrawal. Class I anti-arrhythmic drugs (e.g. disopyramide) and amiodarone may potentiate effects on atrial-conduction time and induce negative inotropic effect. May increases hypoglycaemic effects of insulin and oral antidiabetic drugs. Decreased hypotensive effects with concomitant use of NSAIDs (e.g. ibuprofen, indometacin). May increases risk of hypotension and attenuates reflex tachycardia with anaesthetic drugs.
ATC Classification
C07AB03 - atenolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Disclaimer: This information is independently developed by CIMS based on atenolol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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