Atenolol


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Patients with bradycardia, cardiogenic shock, hypotension, metabolic acidosis, 2nd or 3rd degree heart block, severe peripheral arterial disease, sick sinus syndrome (without pacemaker), uncompensated cardiac failure, and untreated phaeochromocytoma.
Special Precautions
Patients with bronchospasm or reversible obstructive airways disease, diabetes mellitus, peripheral vascular disease, Raynaud's disease, Prinzmetal's angina, myasthenia gravis, psoriasis and thyroid diseases. Avoid abrupt withdrawal. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor blood pressure, heart rate, ECG, and serum glucose (in patients with diabetes mellitus).
Adverse Reactions
Blood and lymphatic system disorders: Thrombocytopenia. Cardiac disorders: Bradycardia. Eye disorders: Dry eyes, visual disturbances. Gastrointestinal disorders: Nausea, diarrhoea, dry mouth. General disorders and administration site conditions: Fatigue. Musculoskeletal and connective tissue disorders: Lupus-like syndrome. Nervous system disorders: Dizziness, headache. Psychiatric disorders: Hallucinations, depression, nightmare, psychoses. Reproductive system and breast disorders: Impotence. Skin and subcutaneous tissue disorders: Psoriasiform skin reactions, purpura, alopecia. Vascular disorders: Postural hypotension, cold extremities, Raynaud's phenomenon.
Drug Interactions
Additive effects with Ca channel blockers (e.g. verapamil, diltiazem) and catecholamine-depleting agents (e.g. reserpine). May increase atrioventricular conduction time with digitalis glycosides. May aggravate rebound hypertension following clonidine withdrawal. Class I anti-arrhythmic drugs (e.g. disopyramide) and amiodarone may potentiate effects on atrial-conduction time and induce negative inotropic effect. May increases hypoglycaemic effects of insulin and oral antidiabetic drugs. Decreased hypotensive effects with concomitant use of NSAIDs (e.g. ibuprofen, indometacin). May increases risk of hypotension and attenuates reflex tachycardia with anaesthetic drugs.
ATC Classification
C07AB03 - atenolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
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