Atorvastatin + ezetimibe


Concise Prescribing Info
Indications/Uses
Hypercholesterolaemia.
Dosage/Direction for Use
Adult: PO Per tab contains atorvastatin 10 mg and ezetimibe 10 mg: 1 tab once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.
Special Precautions
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr.
Adverse Reactions
Headache, flatulence, dyspepsia, myalgia, rash, pruritus, allergy and infection. Abdominal discomfort, asthenia, constipation, diarrhoea, back pain, arthralgia, resp infection and fatigue.
Drug Interactions
Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels.
ATC Classification
C10AX09 - ezetimibe ; Belongs to the class of other lipid modifying agents.
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Disclaimer: This information is independently developed by CIMS based on atorvastatin + ezetimibe from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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