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Indications/Uses
Susceptible infections.
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Dosage/Direction for Use
Adult: IV 2 g 8 hrly; life threatening infections: 5 g 8 hrly.
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Contraindications
Hypersensitivity to penicillins.
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Special Precautions
Restricted sodium diet. Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.
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Adverse Reactions
Pain at the inj site and phlebitis; electrolyte disturbances; dose-dependent coagulation defect; purpura and haemorrhage; hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis. |
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Drug Interactions
Probenecid prolongs T1/2 of azlocillin. Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
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CIMS Class
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ATC Classification
J01CA09 - azlocillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
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