Bacampicillin

Oral
Urinary tract infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Bronchitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Perinatal streptococcal infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Typhoid and paratyphoid fever
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Gastroenteritis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Listeriosis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Biliary tract infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Endocarditis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Septicaemia
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Pneumonia
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Peritonitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Otitis media
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Meningitis
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Uncomplicated gonorrhoea
Adult: 1.6 g with 1 g probenecid as a single dose.

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins.

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.

Probenecid prolongs T_1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.

Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.
Absorption: Rapidly and absorbed in the GI tract.
Metabolism: Hydrolysed in intestinal walls and plasma to ampicillin.
Excretion: About 75% of a dose is excreted in the urine within 8 hr as ampicillin.

Penicillins

J01CA06 - bacampicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.