Benserazide


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Parkinson's disease
Adult: Usually given with L-dopa in the ratio of 1 part of benserazide base to 4 parts of L-dopa. As capsule containing levodopa 100 mg and benserazide 25 mg: Initially, 1 capsule 1-2 times/day; increase every 3-4 days until therapeutic effect; optimal dosage: 4-8 capsules/day, given in 4-6 divided doses. Max (per day): Levodopa 1200 mg/ benserazide 300 mg.
Administration
Should be taken on an empty stomach. When introduced, take w/ meals to reduce GI discomfort.
Contraindications
Avoid in patients <25 yr, pregnancy or women of child-bearing potential in the absence of adequate contraception.
Action
It is a peripheral dopa-decarboxylase inhibitor with little or no pharmacological activity when used alone. It inhibits peripheral decarboxylation of L-dopa to dopamine, thus effective brain concentrations of dopamine are produced with lower doses of L-dopa. It is used as an adjunct to levodopa in the treatment of parkinsonism.
Absorption: Rapidly absorbed (approx 58%). Concurrent admin with L-dopa increases the absorption slightly.
Metabolism: Mainly metabolised in the gut.
Excretion: Rapidly excreted as metabolites in the urine mostly within the 1st 6 hr; 85% excretion within 12 hr.
Storage
Oral: Store at 15-30°C.
CIMS Class
Antiparkinsonian Drugs
Disclaimer: This information is independently developed by CIMS based on benserazide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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