Betamethasone + fusidic acid


Full Generic Medicine Info
Dosage/Direction for Use

Topical/Cutaneous
Corticosteroid-responsive dermatoses with secondary infection
Adult: Available preparation Each cream contains betamethasone valerate 0.1 % and fusidic acid 2% Each cream contains betamethasone dipropionate 0.064% and fusidic acid 2% Each oint contains betamethasone dipropionate 0.064% and sodium fusidate 2% Apply onto affected area(s) bid. Max duration: 2 weeks.
Contraindications
Skin lesions of viral, fungal or bacterial origin (e.g. herpes or varicella), skin manifestations in relation to TB or syphilis, perioral dermatitis and rosacea, ulcerative condition.
Special Precautions
May increase risk of developing antibiotic resistance. Stasis dermatitis and other skin disease w/ impaired circulation. Not to be used for >7 days if there is no clinical improvement. Avoid prolonged continuous treatment esp in infants and childn. Pregnancy and lactation. Patient Counselling Avoid contact w/ eyes as it may cause glaucoma.
Adverse Reactions
Hypersensitivity, contact dermatitis, eczema (aggravated condition), skin burning sensation, pruritus, dry skin, application site pain or irritation. Rarely, erythema, urticaria (including rash erythematous and generalised rash), application site swelling or vesicles.
Overdosage
Symptoms: Cushing's syndrome and adrenocortical insufficiency. Management: Symptomatic treatment.
Action
Betamethasone is a topical fluorinated corticosteroid that has an anti-inflammatory and antipruritic effect. Fusidic acid is a potent topical antibacterial agent which is effective against Staphylococcus aureus, Streptococci, Corynebacteria, Neiserria and certain Clostridia and Bacteroides.
Absorption: Betamethasone: Absorption through the skin is increased under occlusive dressing or when there is broken skin at the site of application.
Distribution: Betamethasone: Bound to plasma proteins to varying extent. Fusidic acid: Widely distributed into tissues and body fluids (including bone, pus, synovial fluid); penetrate cerebral abscesses but does not enter cerebrospinal fluid in appreciable amounts. Enters foetal circulation and breast milk. Plasma protein binding: Approx ≥95% as fusidic acid or Na fusidate.
Metabolism: Betamethasone: Mainly metabolised in the liver and limited extent in the kidneys.
Excretion: Betamethasone: Via urine as inactive metabolites. Fusidic acid/Na fusidate: Mainly in the bile via faeces (approx 2%) as unchanged drug; urine (small amounts).
Storage
Topical/Cutaneous: Store at or below 30°C. Protect from light.
CIMS Class
Topical Anti-Infectives with Corticosteroids
ATC Classification
S01BA06 - betamethasone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
D09AA02 - fusidic acid ; Belongs to the class of ointment dressings with antiinfectives.
C05AA05 - betamethasone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.
J01XC01 - fusidic acid ; Belongs to the class of steroid antibacterials. Used in the systemic treatment of infections.
H02AB01 - betamethasone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
S01CB04 - betamethasone ; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.
D07XC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
R03BA04 - betamethasone ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticoids.
D07AC01 - betamethasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
S01AA13 - fusidic acid ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
D06AX01 - fusidic acid ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
A07EA04 - betamethasone ; Belongs to the class of corticosteroids acting locally. Used in the treatment of intestinal inflammation.
R01AD06 - betamethasone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
S02BA07 - betamethasone ; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear.
S03BA03 - betamethasone ; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations.
Disclaimer: This information is independently developed by CIMS based on betamethasone + fusidic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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