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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO HTN Initial: 10 mg once daily, may increase to 20 mg/day after 1-2 wk if needed. Ophth Ocular HTN; Open-angle glaucoma As 0.25% or 0.5% drop: Instill 1 drop bid.
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Administration
May be taken with or without food.
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Contraindications
Sick sinus syndrome, severe bradycardia, cardiogenic shock, uncontrolled cardiac failure, 2nd or 3rd degree AV block, severe bronchial asthma, severe COPD, metabolic acidosis, untreated phaeochromocytoma, severe peripheral arterial disease.
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Special Precautions
Patients w/ bronchospastic disease, DM, corneal disease. May mask signs of hyperthyroidism and acute hypoglycaemia. Avoid abrupt withdrawal as it may exacerbate angina, MI, ventricular arrhythmias and precipitate thyroid storm. Patients undergoing surgery involving general anaesth. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor BP, pulse and baseline renal function.
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Adverse Reactions
Eye discomfort (stinging and burning), bradycardia, palpitation, chest pain, oedema, insomnia, fatigue, lethargy, nausea, dyspepsia, diarrhoea, arthralgia, paraesthesia, dyspnoea, pharyngitis, antinuclear antibody positive, cold extremities.
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Drug Interactions
Increased risk of bradycardia w/ digitalis glycosides. May cause mydriasis w/ epinephrine. Potential additive effect w/ oral Ca channel blockers, β-adrenergic blockers, antiarrhythmics (including amiodarone), parasympathomimetics, guanethidine. Increased risk of myocardial depression and hypotension w/ peripheral muscle relaxants (e.g. tubocurarine).
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CIMS Class
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ATC Classification
S01ED02 - betaxolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
C07AB05 - betaxolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases. |
