Bimatoprost

Ophthalmic
Ocular hypertension
Adult: As 0.01% or 0.03% soln: Instill 1 drop into the affected eye(s) once daily at bedtime.

Ophthalmic
Open-angle glaucoma
Adult: As 0.01% or 0.03% soln: Instill 1 drop into the affected eye(s) once daily at bedtime.

Ophthalmic
Hypotrichosis of eyelashes
Adult: As 0.03% soln: Apply 1 drop evenly to each eye along the skin of the upper eyelid at the base of eyelashes once daily at bedtime.

Patient w/ active intraocular inflammation (e.g. uveitis), aphakic patient, pseudophakic patient w/ torn posterior lens capsule, risk factor for macular oedema; history of herpes simplex, or uveitis/irits. Pregnancy and lactation. Patient Counselling Remove contact lenses prior to admin and reinsert after 15 min. May cause discolouration of soft contact lenses. Monitoring Parameters Monitor intraocular pressure.

Ocular pruritus, swelling, irritation and burning sensation; conjunctival hyperaemia, dry eye symptoms, blurred vision, periorbital erythema, increased lacrimation, madarosis, trichorrhex, skin hyperpigmentation and discolouration, growth and darkening of eyelashes, hypersensitivity, rash (including macular, erythematous, and pruritic limited to eyelids and periorbital region); eyelid oedema, irritation and pruritus; periorbital and lid changes resulting in deepening of eyelid sulcus; headache, HTN, abnormal LFT.

May increase intraocular pressure w/ latanoprost. May reduce therapeutic effect w/ NSAIDs.

Bimatoprost, a synthetic prostamide analogue, reduces intraocular pressure by increasing the outflow of aqueous humour. It also increases the percent and duration of hair in the growth phase.
Onset: Approx 4 hr.
Absorption: Absorbed through the cornea and sclera. Time to peak plasma concentration: W/in 10 min.
Distribution: Moderately distributed into body tissues. Volume of distribution: 0.67 L/kg. Plasma protein binding: Approx 88%.
Metabolism: Undergoes oxidation, N-deethylation and glucuronidation to form various metabolites.
Excretion: Via urine (up to 76%); faeces (25%). Elimination half-life: Approx 45 min.

Ophthalmic: Store between 2-25°C.

Antiglaucoma Preparations / Other Eye Preparations

S01EE03 - bimatoprost ; Belongs to the class of prostaglandin analogues. Used in the treatment of glaucoma.