Significant: Adrenal suppression (e.g. suppression of hypothalamic-pituitary-adrenal axis, hypercortisolism, Cushing's syndrome), immunosuppression (prolonged use), growth retardation in children, hyperglycemia, fluid retention, decreased bone mineral density, Kaposi sarcoma (prolonged use), acute myopathy, pneumonia, delayed wound healing, visual disturbances (e.g. blurred vision, glaucoma, cataract, central serous chorioretinopathy), oral candidiasis. Rarely, vasculitis or other systemic eosinophilic conditions, psychiatric disturbances (e.g. psychomotor hyperactivity, insomnia, euphoria, mood swings, personality changes, anxiety, depression, aggression or psychotic manifestations), hypersensitivity reactions (e.g. anaphylaxis, angioedema, bronchospasm, contact dermatitis, rash, urticaria).
Cardiac disorders: Palpitation.
Gastrointestinal disorders: Nausea, abdominal pain, abdominal distension, dry mouth, dyspepsia, flatulence, diarrhoea, GERD, constipation.
General disorders and administration site conditions: Fatigue, malaise.
Infections and infestations: Oesophageal or oropharyngeal candidiasis, influenza.
Investigations: Blood cortisol decreased.
Metabolism and nutrition disorders: Hypokalaemia.
Musculoskeletal and connective tissue disorders: Myalgia, back pain, muscle spasms.
Nervous system disorders: Headache, dizziness, tremor.
Reproductive system and breast disorders: Menstrual disorder.
Respiratory, thoracic and mediastinal disorders: Cough, hoarseness, throat irritation, nasal ulcer, nasal septum perforation, epitaxis, nasal mucosa irritation.
Skin and subcutaneous tissue disorders: Acne, pruritus, exanthema, petechiae, bruising.
Vascular disorders: Hypertension.
Potentially Fatal: Adrenal insufficiency, paradoxical bronchospasm; chickenpox or measles infection (in immunosuppressed patients).