Butamirate: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Contraindications Special Precautions Adverse Reactions Overdosage Drug Interactions Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Full Generic Medicine Info

Dosage/Direction for Use

Oral
Non-productive cough
Adult: For the symptomatic relief of cases: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 22.5 mg (15 mL) up to 4 times daily. Max: 90 mg (60 mL) daily. Dosage recommendations may vary among countries or individual products (refer to specific product guidelines.
Child: Dosage recommendations may vary among countries or individual products (refer to specific product guidelines).

Contraindications

Children <18 years. 1st trimester of pregnancy.

Special Precautions

Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness or dizziness, if affected, do not drive or operate machinery.

Adverse Reactions

Gastrointestinal disorders: Nausea, diarrhoea. Immune system disorders: Hypersensitivity reaction. Nervous system disorders: Drowiness, dizziness. Skin and subcutaneous tissue disorders: Rash, urticaria.

Overdosage

Symptoms: Nausea, vomiting, diarrhoea, somnolence, dizziness, hypotension. Management: Supportive treatment.

Drug Interactions

Concomitant use with other cough medicines may cause an accumulation of bronchial secretions in the lungs.

Action

Butamirate is an antitussive structurally unrelated to opioids. To suppress cough, it acts centrally by decreasing the tussigenic reflex. It also has peripheral anti-inflammatory and bronchospasmolytic activity.
Absorption: Rapidly and completely absorbed. Time to peak plasma concentration: 1.5 hours (syr).
Distribution: Plasma protein binding: Approx 95%.
Metabolism: Metabolised via hydrolysis into 2-phenyl butyric acid and diethylaminoethoxyethanol.
Excretion: Via urine (as metabolites). Elimination half-life: 6 hours.

Storage

Oral: Store below 30°C.

CIMS Class

Cough & Cold Preparations

ATC Classification

R05DB13 - butamirate ; Belongs to the class of other cough suppressants.

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