Capreomycin


Full Generic Medicine Info
Dosage/Direction for Use

Parenteral
Tuberculosis
Adult: 1 g daily, by deep IM inj or IV infusion, for 2-4 mth, then 2-3 times wkly for the remainder of the therapy. Max: 20 mg/kg/day.
Child: 15-30 mg/kg daily. Max: 1 g/day.
Renal impairment: Dose reduction needed based on CrCl.
Contraindications
Hypersensitivity to capreomycin and other aminoglycosides.
Special Precautions
Patient w/ pre-existing auditory impairment. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor auditory, vestibular and renal function at baseline and during therapy; frequent assessment of serum electrolytes (e.g. Ca, Mg, K) and liver function.
Adverse Reactions
Ototoxicity; hypokalaemia, hypocalcaemia, hypomagnesaemia and an electrolyte disturbance resembling Bartter's syndrome; leukocytosis, leucopenia, eosinophilia; hypersensitivity reactions (e.g. urticaria, photosensitivity, maculopapular rash) associated w/ fever; abnormal LFT results; partial neuromuscular blockade; pain, induration, excessive bleeding and sterile abscess on inj site.
Potentially Fatal: Nephrotoxicity, neuromuscular blockade or resp paralysis.
Overdosage
Symptoms: Hypokalaemia, hypocalcaemia, hypomagnesaemia and an electrolyte disturbance resembling Bartter's syndrome; nephrotoxicity (e.g. acute tubular necrosis) and ototoxicity (e.g. dizziness, tinnitus, vertigo, loss of high-tone acuity). Management: Symptomatic and supportive treatment. May administer activated charcoal to reduce absorption.
Drug Interactions
Additive and sometimes irreversible toxic effects w/ other parenteral anti-TB agents (e.g. streptomycin, viomycin). Increased risk of nephrotoxicity and ototoxicity w/ other non-antituberculosis drugs (e.g. polymyxin A sulfate, amikacin, gentamicin, tobramycin, vancomycin, kanamycin, neomycin).
Action
Capreomycin is a cyclic polypeptide antimicrobial. It is bacteriostatic against various Mycobacteria, particularly those that have become resistant to primary anti-TB drugs.
Absorption: Poorly absorbed from the GI tract. Time to peak plasma concentration: 1-2 hr (IM).
Excretion: Via urine (approx 50%, as unchanged drug) by glomerular filtration w/in 12 hr.
Storage
Parenteral: Store between 15-30°C. Reconstituted soln: Store between 2-8°C, stable for 24 hr.
CIMS Class
Anti-TB Agents
ATC Classification
J04AB30 - capreomycin ; Belongs to the class of antibiotics. Used in the systemic treatment of tuberculosis.
Disclaimer: This information is independently developed by CIMS based on capreomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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