Cefaclor


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to cefaclor or to other cephalosporins.
Special Precautions
Hypersensitivity to penicillins. History of GI disease. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor renal function. Observe for signs of anaphylaxis during 1st dose.
Adverse Reactions
GI effects (e.g. diarrhoea, nausea, vomiting), headache, rash. Rarely, serum sickness-like reactions consisting of erythema multiforme or maculopapular pruritic rash or urticaria accompanied by arthritis, arthralgia, irritability and fever.
Potentially Fatal: Severe hypersensitivity reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis and anaphylaxis), pseudomembranous colitis.
Drug Interactions
May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.
CIMS Class
Cephalosporins
ATC Classification
J01DC04 - cefaclor ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
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