Cefadroxil: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Full Generic Medicine Info

Dosage/Direction for Use Administration Contraindications Special Precautions Adverse Reactions Pregnancy Category (US FDA) Overdosage Drug Interactions Lab Interference Action Storage CIMS Class ATC Classification

This information is not country-specific. Please refer to the India prescribing information.

Generic Medicine Info

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Contraindications

Hypersensitivity to cefadroxil or other cephalosporins.

Special Precautions

Patient with history of hypersensitivity to penicillins or any other β-lactam drugs, severe allergy or asthma; history of gastrointestinal disease, especially colitis. Renal impairment. Pregnancy and lactation. Monitoring Parameters Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Monitor renal function test, LFTs and blood count frequently on long-term use; signs and symptoms of anaphylaxis during 1st dose.

Adverse Reactions

Significant: Hypersensitivity reactions, including anaphylaxis; Clostridium difficile-associated diarrhoea. Blood and lymphatic system disorders: Rarely, eosinophilia, neutropenia, thrombocytopenia, agranulocytosis. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, dyspepsia, abdominal pain, glossitis. General disorders and administration site conditions: Rarely, fever. Immune system disorders: Rarely, serum sickness-like reaction, angioneurotic oedema. Investigations: Rarely, slightly elevated AST and ALT. Musculoskeletal and connective tissue disorders: Rarely, arthralgia. Skin and subcutaneous tissue disorders: Rash, pruritus, allergic exanthema, urticaria.
Potentially Fatal: Pseudomembranous colitis.

Pregnancy Category (US FDA)

Drug Interactions

May cause an antagonistic effect with bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol). May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May cause haemorrhagic complications with prolonged use of anticoagulant or thrombocyte inhibitors. May increase plasma concentration with probenecid. May decrease bioavailability with colestyramine.

CIMS Class

Cephalosporins

ATC Classification

J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.

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