Cefatrizine


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Susceptible infections
Adult: 500 mg bid.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and hematologic status. Pregnancy, lactation.
Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; pseudomembranous colitis; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
Drug Interactions
Renal excretion delayed by probenecid. Decreases contraceptive effect of estrogen-containing oral contraceptives.
Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
Action
Cefatrizine inhibits final cross-linking stage of peptidoglycan production thus inhibiting bacterial cell wall synthesis. It has excellent activity against gram-positive cocci except enterococci at minimal inhibitory concentrations <1 mcg/ml.
CIMS Class
ATC Classification
J01DB07 - cefatrizine ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
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