Cefepime


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: IM/IV Susceptible infections Mild to moderate: 1-2 g/day in 2 divided doses. Severe: Up to 4 g/day in 2 divided doses. Empirical therapy for febrile neutropenia Up to 6 g/day in 3 divided doses.
Contraindications
Hypersensitivity to cefepime or other cephalosporins.
Special Precautions
Hypersensitivity to penicillins or other β-lactam antibiotics. Patient w/ history of seizure disorder, history of GI disease, particularly colitis. Renal impairment. Pregnancy and lactation. Prolonged use may result in overgrowth of non-susceptible organisms. Monitoring Parameters Monitor renal function; signs and symptoms of anaphylaxis during 1st dose.
Adverse Reactions
Headache, rash, diarrhoea, nausea, vomiting, local reactions (e.g. phlebitis, pain and/or inflammation), neutropenia, positive direct Coombs' test.
Potentially Fatal: Neurotoxicity (e.g. encephalopathy, myoclonus, seizures, non-convulsive status epilepticus); Clostridium difficile-associated diarrhoea; anaphylaxis.
Drug Interactions
Increased potential for nephrotoxicity and ototoxicity of aminoglycosides. Increased risk of nephrotoxicity w/ potent diuretics (e.g. furosemide).
CIMS Class
ATC Classification
J01DE01 - cefepime ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on cefepime from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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