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Contraindications
Hypersensitivity to cefepime or other cephalosporins; history of severe hypersensitivity reactions (e.g. anaphylactic reaction) to other β-lactam antibacterial agents (e.g. penicillins, carbapenems, monobactams).
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Special Precautions
Patient with history of non-severe hypersensitivity to other β-lactam agents, asthma, allergic diathesis, seizure disorder, gastrointestinal disease (particularly colitis). Children and elderly. Renal impairment. Pregnancy and lactation. Monitoring Parameters Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Monitor renal function. Assess for signs and symptoms of anaphylaxis during the initial dose.
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Adverse Reactions
Significant: Elevated INR; fungal or bacterial superinfection (prolonged use).
Blood and lymphatic system disorders: Anaemia, eosinophilia.
Gastrointestinal disorders: Diarrhoea, nausea, vomiting.
General disorders and administration site conditions: Localised reactions (e.g. phlebitis, inflammation and/or pain), fever.
Investigations: Increased AST, ALT, alkaline phosphatase, blood bilirubin; prolonged partial thromboplastin time.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash, pruritus.
Potentially Fatal: Hypersensitivity reactions; Pseudomembranous colitis, Clostridium difficile-associated diarrhoea; neurotoxicity e.g. encephalopathy, aphasia, myoclonus, seizures, non-convulsive status epilepticus (in patients with renal impairment who did not receive appropriate dosage adjustment). |
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Drug Interactions
May potentiate the action of coumarin anticoagulants. May enhance the nephrotoxic effects of aminoglycosides or potent diuretics (e.g. furosemide).
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CIMS Class
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ATC Classification
J01DE01 - cefepime ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.
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