Cefixime

May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.

Hypersensitivity to cephalosporins.

Patient with history of hypersensitivity to penicillin and other beta-lactam antibiotics, poor nutritional state, history of gastrointestinal disease, particularly colitis. Renal and hepatic impairment. Children. Pregnancy and lactation. Monitoring Parameters Monitor renal and hepatic functions periodically. Observe for signs and symptoms of anaphylaxis during 1st dose.

Significant: Encephalopathy (including convulsion, confusion, impairment of consciousness, movement disorders), acute renal failure (including tubulointerstitial nephritis). Blood and lymphatic system disorders: Transient thrombocytopenia, leucopenia, neutropenia, pancytopenia, agranulocytosis, eosinophilia. Gastrointestinal disorders: Diarrhoea, loose or frequent stools, abdominal pain, nausea, vomiting, dyspepsia, flatulence. Hepatobiliary disorders: Hepatitis, jaundice, hyperbilirubinaemia. Immune system disorders: Hypersensitivity reactions including rash, pruritus, urticaria, drug fever. Investigations: Transient elevations in SGPT, SGOT, alkaline phosphatase, BUN and creatinine; increased LDH. Rarely, prolonged prothrombin time. Nervous system disorders: Headaches, dizziness, seizures. Reproductive system and breast disorders: Genital pruritus, vaginitis, candidiasis.
Potentially Fatal: Severe cutaneous adverse reactions (SCARS) including toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS) drug rash with eosinophilia and systemic symptoms (DRESS), and acute generalised exanthematous pustulosis (AGEP), haemolytic anaemia, pseudomembranous colitis, anaphylactic/anaphylactoid reactions (including shock).

May enhance the effects of anticoagulants (e.g. warfarin) resulting in prolonged prothrombin time. May increase carbamazepine levels.

Cephalosporins

J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.