Cefpodoxime


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Urinary tract infections
Adult: 100-200 mg 12 hrly.
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min)Dosage Recommendation
<10Increase dosing intervals to 48 hrly.
10-39Increase dosing intervals to 24 hrly.

Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Oral
Respiratory tract infections
Adult: 100-200 mg 12 hrly.
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min)Dosage Recommendation
<10Increase dosing intervals to 48 hrly.
10-39Increase dosing intervals to 24 hrly.

Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Oral
Skin and soft tissue infections
Adult: 200-400 mg 12 hrly.
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min)Dosage Recommendation
<10Increase dosing intervals to 48 hrly.
10-39Increase dosing intervals to 24 hrly.

Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Oral
Acute otitis media
Child: ≥15 days 4 mg/kg 12 hrly. Max: 200 mg daily.
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min)Dosage Recommendation
<10Increase dosing intervals to 48 hrly.
10-39Increase dosing intervals to 24 hrly.

Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.

Oral
Uncomplicated gonorrhoea
Adult: 200 mg as a single dose.
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min)Dosage Recommendation
<10Increase dosing intervals to 48 hrly.
10-39Increase dosing intervals to 24 hrly.

Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to cefpodoxime or other cephalosporins.
Special Precautions
Patient w/ history of penicillin allergy. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor renal function; observe for signs and symptoms of anaphylaxis during 1st dose.
Adverse Reactions
Diarrhoea, nausea, abdominal pain, vomiting, diaper and skin rash, headache, vag infection. Anxiety, chest pain, cough, decreased appetite, dizziness, dysgeusia, epistaxis, eye pruritus, fatigue, fever, flatulence, flushing, fungal skin infection, hypotension, insomnia, malaise, nightmares, pruritus, purpuric nephritis, tinnitus, weakness, xerostomia, vulvovaginal candidiasis.
Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea and colitis.
Overdosage
Symptoms: Nausea, vomiting, epigastric distress and diarrhoea. Management: Haemodialysis or peritoneal dialysis may be useful in the event of a serious toxic reaction particularly if renal function is compromised.
Drug Interactions
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.
Food Interaction
Cefpodoxime levels may be increased w/ food.
Lab Interference
Urinary glucose test using cupric sulfate (e.g. Benedict's or Fehling's tests soln, Clinitest®) may produce false-positive result. May induce a positive direct Coombs' test; false-positive serum or urine creatinine w/ Jaffe' reaction.
Action
Cefpodoxime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Rapid and well absorbed from the GI tract (approx 50%). Decreased absorption in low gastric acidity conditions. Food may increase bioavailability. Bioavailability: Approx 50%. Time to peak plasma concentration: Approx 2-3 hr.
Distribution: Reaches bile, resp and genito-urinary tract (therapeutic concentrations); enters breast milk (low concentrations). Plasma protein binding: Approx 20-30%.
Metabolism: De-esterified to cefpodoxime in the intestinal lumen.
Excretion: Via urine (80% as unchanged drug). Plasma half-life: Approx 2-3 hr.
Storage
Oral: Store between 20-25°C. Reconstituted powd: Store between 2-8°C.
CIMS Class
ATC Classification
J01DD13 - cefpodoxime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on cefpodoxime from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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