Generic Medicine Info
Hypersensitivity to cephalosporins or history of severe hypersensitivity to other type of β-lactam antibiotic (e.g. penicillins, monobactams, carbapenems). Premature neonates up to a postmenstrual age of 41 weeks (gestational age and chronological age), full term neonates (up to 28 days of age) with hyperbilirubinaemia, jaundice, hypoalbuminaemia, or acidosis requiring IV Ca treatment, or Ca containing infusions.
Special Precautions
Patient with history of allergy to penicillins or any drug, and history of gastrointestinal disease (e.g. colitis), renal lithiasis; hypercalciuria, impaired vit K synthesis or low vit K stores. Severe renal and hepatic impairment. Children. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor prothrombin time/INR. Monitor signs and symptoms of hypersensitivity.
Adverse Reactions
Significant: Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/Lyell's syndrome, hypersensitivity, renal and gallbladder precipitation, pancreatitis secondary to biliary obstruction, renal lithiasis, superinfection. Blood and lymphatic system disorders: Eosinophilia, leucopenia, thrombocytopenia. Gastrointestinal disorders: Diarrhoea, oral candidiasis. General disorders and administration site conditions: Diaphoresis. Injury, poisoning and procedural complications: Pain, induration and tenderness at injection site (IM). Investigations: Increased hepatic enzymes, BUN and serum creatinine; sonographic abnormalities in the gallbladder. Nervous system disorders: Headache, dizziness. Reproductive system and breast disorders: Candidal vaginitis. Skin and subcutaneous tissue disorders: Rash. Vascular disorders: Flushing.
Potentially Fatal: Severe haemolytic anaemia, Clostridium difficile associated diarrhoea (CDAD).
Drug Interactions
May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate.
CIMS Class
ATC Classification
J01DD04 - ceftriaxone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
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