Manage Account
Change Password
Sign Out
UserName
Profession Email
Profession Email
|
Indications/Uses
Hypercholesterolaemia.
|
|
Dosage/Direction for Use
Adult: PO Initial: 100 mcg once daily in the evening, may increase by increments of 100 mcg at intervals of at least 4 wk. Max: 300 mcg/day.
|
|
Contraindications
Active liver disease or unexplained persistent elevated serum transaminase levels; porphyria. Pregnancy.
|
|
Special Precautions
Severe renal impairment. Monitoring Parameters Monitor LFT.
|
|
Adverse Reactions
GI disturbances, dysgeusia; headache, dizziness, insomnia; rashes; blurred vision. Rarely, HTN; somnolence. oedema, fever, abnormal laboratory test, angina pectoris, anorexia, colitis, duodenal ulcer, GI haemorrhage, anaemia, leucopaenia, increased amylase, myopathy, hyperkinesia, paralysis, corneal ulcer, abnormal renal function.
Potentially Fatal: Hepatitis, pancreatitis, severe rhabdomyolysis. |
|
Drug Interactions
May increase risk of rhabdomyolysis w/ HIV protease inhibitors. May increase risk of myopathy w/ immunosuppressants, fibric acid derivatives, nicotinic acid. Increased bleeding risk w/ anticoagulants. Increased plasma levels w/ mibefradil.
|
|
CIMS Class
|
