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Administration
Extended-release: May be taken with or without food. Swallow whole, do not chew/crush.
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Contraindications
Narrow angle glaucoma, urinary retention, severe hypertension, severe coronary artery disease. Children below 12 years. Concomitant or within 14 days of MAOI use.
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Special Precautions
Patient with CV disease (e.g. hypertension, ischaemic heart disease), diabetes mellitus, increased intraocular pressure, thyroid dysfunction, urinary obstruction (including prostatic hypertrophy). Renal and hepatic impairment. Elderly. Treatment with cold medicines in children should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation. Patient Counselling This drug may cause CNS depression (e.g. somnolence), if affected, do not drive or operate machinery.
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Adverse Reactions
Significant: CNS stimulation or depression, CV collapse with hypotension.
Cardiac disorders: Tachycardia, palpitation.
Gastrointestinal disorders: Dry mouth, nausea.
General disorders and administration site conditions: Asthenia, restlessness, weakness, ataxia.
Metabolism and nutrition disorders: Anorexia.
Nervous system disorders: Headache, dizziness, vertigo, convulsions.
Psychiatric disorders: Insomnia, anxiety, fear, nervousness, hallucinations, dysphonia.
Renal and urinary disorders: Dysuria.
Respiratory, thoracic and mediastinal disorders: Respiratory difficulty, epistaxis, pharyngitis.
Vascular disorders: Pallor.
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Drug Interactions
Increased pharmacological effect with CNS depressants.
Pseudoephedrine: Increased ectopic pacemaker activity may occur when given with digitalis. May decrease pharmacological effect of antihypertensive agents that interfere with sympathetic activity (e.g. reserpine, methyldopa).
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CIMS Class
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ATC Classification
S01GX12 - cetirizine ; Belongs to the class of other ophthalmologic antiallergics.
R01BA02 - pseudoephedrine ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants. R06AE07 - cetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines. |
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