Chenodeoxycholic acid


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Non-visualising gallbladder after two successive single doses of dye. Radiopaque stones. Gallstone complications or reasons necessitating gallbladder surgery (e.g. unremitting acute cholecystitis, cholangitis, biliary obstruction, gallstone pancreatitis, or biliary gastrointestinal fistula). Hepatic impairment, hepatocyte dysfunction or bile ductal abnormalities (e.g. intrahepatic cholestasis, primary biliary cirrhosis, sclerosing cholangitis). Pregnancy.
Special Precautions
Lactation. Monitoring Parameters Monitor serum aminotransferase monthly for first 3 months, then every 3 months thereafter during therapy; serum cholesterol every 6 months; oral cholecystograms and ultrasonograms at 6-9 month intervals. Confirm stone dissolution after 1-3 months of treatment.
Adverse Reactions
Significant: Diarrhoea, hepatotoxicity, colon cancer, gallstone recurrence. Blood and lymphatic system disorders: Leucopenia. Investigations: Increased serum transaminases, increased LDL and total serum cholesterol. Gastrointestinal disorders: Nausea, vomiting, biliary colic, abdominal cramps, abdominal pain, anorexia, constipation, dyspepsia, flatulence.
Drug Interactions
Decreased absorption with bile acid sequestrants (e.g. cholestyramine, colestipol) and aluminium-containing antacids. Increased biliary cholesterol secretion and reduced efficacy with fibric acid derivatives (e.g. clofibrate) and oestrogen derivatives. May increase the anticoagulant effect of vitamin K antagonists (e.g. warfarin).
ATC Classification
A05AA01 - chenodeoxycholic acid ; Belongs to the class of bile acids. Used in bile therapy.
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