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Dosage/Direction for Use
Intramuscular Male infertility due to hypogonadotropic hypogonadism Adult: 500-1,000 units 2-3 times weekly. Child: Intramuscular Anovulatory infertility Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency. Intramuscular Delayed puberty associated with hypogonadism in males Adult: Male: 1,500 units twice weekly for at least 6 months. |
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Contraindications
Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.
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Special Precautions
Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.
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Adverse Reactions
Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain.
Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS). |
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Action
Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Absorption: Peak concentrations after 6 hrs (IM). Distribution: Mainly in the gonads. Excretion: Via the urine (10-12% of IM dose within 24 hrs). Elimination half-life: 6-11 hrs (initial phase), 23-38 hrs (terminal phase). |
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Storage
Intramuscular: Store at 15-30°C.
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CIMS Class
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ATC Classification
G03GA01 - chorionic gonadotrophin ; Belongs to the class of gonadotropins. Used as ovulation stimulants.
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