Ciprofloxacin + tinidazole


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult: PO As tab containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300. Usually 1 tab twice daily for 5-10 days depending on severity and response.
Contraindications
Hypersensitivity, patients with a history of blood dyscrasias.
Special Precautions
Renal impairment, history of seizures; ensure adequate hydration & urinary output; avoid alcohol ingestion. Not recommended for use in lactation and pregnancy. Not recommended for children. Patients with CNS disorders. Inadequate water intake during treatment may cause crystalluria.
Adverse Reactions
Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes.
Potentially Fatal: Severe hypersensitivity reaction (rarely).
Drug Interactions
Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.
ATC Classification
P01AB02 - tinidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
J01MA02 - ciprofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
J01XD02 - tinidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections.
S01AE03 - ciprofloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
S03AA07 - ciprofloxacin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
S02AA15 - ciprofloxacin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
Disclaimer: This information is independently developed by CIMS based on ciprofloxacin + tinidazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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